Канал: Narayan Lab, University of Michigan

Biocatalysis & Protein Engineering Meet-up

Biocatalysis & Protein Engineering Meet-up

Simon Burgener – Expanding the one-carbon chemistry of thiamin-dependent enzymes

Simon Burgener – Expanding the one-carbon chemistry of thiamin-dependent enzymes

Brandon Bloomer – A Mechanistic Investigation of Carbene Transfer by an Artificial Metalloenzyme

Brandon Bloomer – A Mechanistic Investigation of Carbene Transfer by an Artificial Metalloenzyme

Richard Obexer – Discovery of Macrocyclic Peptides Against a Membrane Transporter

Richard Obexer – Discovery of Macrocyclic Peptides Against a Membrane Transporter

Johannes Rebelein – Engineering Artificial Metalloenzymes: the Biology-Chemistry Nexus for Catalysis

Johannes Rebelein – Engineering Artificial Metalloenzymes: the Biology-Chemistry Nexus for Catalysis

Daniel Ohde – Enzymaster: Tyrosine Synthesis

Daniel Ohde – Enzymaster: Tyrosine Synthesis

Pascal Püllmann – Accessing and Engineering fungal Peroxygenases through a modular two-yeast system

Pascal Püllmann – Accessing and Engineering fungal Peroxygenases through a modular two-yeast system

Tyler Korman – Development of Cell-free Systems for Terpene and Terpenoid Production

Tyler Korman – Development of Cell-free Systems for Terpene and Terpenoid Production

Thomas Bartholow – Elucidation & Engineering Protein-Protein Interactions Carrier Protein Pathways

Thomas Bartholow – Elucidation & Engineering Protein-Protein Interactions Carrier Protein Pathways

Jill Caswell – Biocatalytic strategies towards oligonucleotide synthesis

Jill Caswell – Biocatalytic strategies towards oligonucleotide synthesis

Sebastian C. Cosgrove – Continuous flow biocatalysis to enable new enzymatic cascades

Sebastian C. Cosgrove – Continuous flow biocatalysis to enable new enzymatic cascades

Tyler Doyon – Radical tropolone biosynthesis catalyzed by a non-heme iron dependent dioxygenase

Tyler Doyon – Radical tropolone biosynthesis catalyzed by a non-heme iron dependent dioxygenase

Ricard De La Peña – PAthway discovery and metabolic engineering of complex plant diterpenes

Ricard De La Peña – PAthway discovery and metabolic engineering of complex plant diterpenes

Nicole Leferink – Biocatalyst engineering and synthetic biology platform for monoterpenes in E. coli

Nicole Leferink – Biocatalyst engineering and synthetic biology platform for monoterpenes in E. coli

Karen Khar – Cyrus Biotechnology: Biomolecules by Desidn. Powered by Rosetta

Karen Khar – Cyrus Biotechnology: Biomolecules by Desidn. Powered by Rosetta

Fetma Feyza Özgen – Challenge Accepted: Harnessing Power of Light to Drive Photobiocatalytic Rxns

Fetma Feyza Özgen – Challenge Accepted: Harnessing Power of Light to Drive Photobiocatalytic Rxns

Jon Ellis – Biocatalytic C-C Bond Formation Through Novel Decarboxylative Aldol-Type Transformation

Jon Ellis – Biocatalytic C-C Bond Formation Through Novel Decarboxylative Aldol-Type Transformation

Catherine McKenna – A Natural Product Inspired Amine Donor for Transaminase Enzymes

Catherine McKenna – A Natural Product Inspired Amine Donor for Transaminase Enzymes

Hayley Knox – Structural basis for non-radical catalysis by TsrM, a radical SAM methylase

Hayley Knox – Structural basis for non-radical catalysis by TsrM, a radical SAM methylase

Monica Neugebauer – Conversion of a hydroxylase to a halogenase through reaction pathway engineering

Monica Neugebauer – Conversion of a hydroxylase to a halogenase through reaction pathway engineering

Rachelle Copeland – A β-Scission Cascade for Ethylene from 2-OG by Microbial Ethylene-Forming Enzyme

Rachelle Copeland – A β-Scission Cascade for Ethylene from 2-OG by Microbial Ethylene-Forming Enzyme

Matthew Thompson – EnginZyme

Matthew Thompson – EnginZyme

Freideriki Michailidou – Engineered SAM synthetases for reversible DNA modification cascade reaction

Freideriki Michailidou – Engineered SAM synthetases for reversible DNA modification cascade reaction

Nick Polizzi – Design of small-molecule-binding proteins

Nick Polizzi – Design of small-molecule-binding proteins

Jason Fang – Aldolase-catalyzed synthesis of chiral organofluorines

Jason Fang – Aldolase-catalyzed synthesis of chiral organofluorines

Maria Laura Mascotti – Ancestral sequence reconstruction of cofactor-dependent enzymes

Maria Laura Mascotti – Ancestral sequence reconstruction of cofactor-dependent enzymes

Melissa Gray – Engineering antibody-sialidase for targeted removal of sialic acids from glycocalyx

Melissa Gray – Engineering antibody-sialidase for targeted removal of sialic acids from glycocalyx

Raphael Hofmann – Site-specific protein modification at internal lysine using E2 conjugating Ubc9

Raphael Hofmann – Site-specific protein modification at internal lysine using E2 conjugating Ubc9

Abigail Herbert – Engineering methyltransferases for use as synthetic tools

Abigail Herbert – Engineering methyltransferases for use as synthetic tools

Rojo Rakotoharisoa – Ensemble enzyme design can repeat effects of lab directed evolution in silico

Rojo Rakotoharisoa – Ensemble enzyme design can repeat effects of lab directed evolution in silico

Page Daniels – Pyrroloiminoquinone biosynthesis: small molecules by post-transnational modification

Page Daniels – Pyrroloiminoquinone biosynthesis: small molecules by post-transnational modification

Lauren J. Rajakovich – Discovery of novel chemistry and enzymes in the human gut microbiota

Lauren J. Rajakovich – Discovery of novel chemistry and enzymes in the human gut microbiota

Jacob DeHovitz – Hydrogen Atom Transfer-based Racemizations in Novel Dynamic Kinetic Resolutions

Jacob DeHovitz – Hydrogen Atom Transfer-based Racemizations in Novel Dynamic Kinetic Resolutions

Michele Tavanti – Development of Polyphosphate Kinases for Scalable ATP Recycling

Michele Tavanti – Development of Polyphosphate Kinases for Scalable ATP Recycling

Tim Gerlach – Get rid of cross-reactivity in biocatalysis: Enzyme inactivation with photosensitizers

Tim Gerlach – Get rid of cross-reactivity in biocatalysis: Enzyme inactivation with photosensitizers

Narayan Lab, University of Michigan Live Stream

Narayan Lab, University of Michigan Live Stream

Julian Wissner – Dioxygenase - Catalyzed Hydroxylation of Heterocyclic Arenes

Julian Wissner – Dioxygenase - Catalyzed Hydroxylation of Heterocyclic Arenes

Alexis Courbet – Towards self-assembling & genetically encodable nanomachines

Alexis Courbet – Towards self-assembling & genetically encodable nanomachines

Steven Fleming – Exploring the Post-translational Enzymology of PaaA by mRNA Display

Steven Fleming – Exploring the Post-translational Enzymology of PaaA by mRNA Display

Hui Chen – The Application of Enzymatic Electosynthesis for the Production of Chiral Chemicals

Hui Chen – The Application of Enzymatic Electosynthesis for the Production of Chiral Chemicals

Christopher Grimm – Oxygen-free enzymatic methyl ether cleavage via transfer catalysis

Christopher Grimm – Oxygen-free enzymatic methyl ether cleavage via transfer catalysis

Miguel A Maria-Solano – Allosterically Driven Conformation ensemble in Tryptophan Synthase evolution

Miguel A Maria-Solano – Allosterically Driven Conformation ensemble in Tryptophan Synthase evolution

Mengbin Chen – Discovery and Biocatalytic Application of PLP-Dependent C-C Bond-Forming Enzymes

Mengbin Chen – Discovery and Biocatalytic Application of PLP-Dependent C-C Bond-Forming Enzymes

Xinkun Ren – Tailoring Myoglobin Carbene Transferases for Selective Intramolecular Cyclopropanations

Xinkun Ren – Tailoring Myoglobin Carbene Transferases for Selective Intramolecular Cyclopropanations

William Finnigan – Computer-aided synthesis planning for biocatalysis

William Finnigan – Computer-aided synthesis planning for biocatalysis

Ryan M. Phelan – EnzyBeads: A new formulation for rapid and accurate biocatalyst dosing

Ryan M. Phelan – EnzyBeads: A new formulation for rapid and accurate biocatalyst dosing

Aaron Debon – Engineering oxidase enzymes by ultra-high throughput screening

Aaron Debon – Engineering oxidase enzymes by ultra-high throughput screening

Tristan de Rond - Biocatalyst Discovery by Co-occurance of Enzyme Domains Reveals Oxazolone Synthase

Tristan de Rond - Biocatalyst Discovery by Co-occurance of Enzyme Domains Reveals Oxazolone Synthase

Directed Evolution of Cytochrome P450 Enzymes for the Asymmetric Amination of C(sp3)-H Bonds

Directed Evolution of Cytochrome P450 Enzymes for the Asymmetric Amination of C(sp3)-H Bonds

Josh Pyser – Chemoenzymatic Synthesis of Azaphilone Natural Products

Josh Pyser – Chemoenzymatic Synthesis of Azaphilone Natural Products

Ashleigh Burke – Design and Evolution of an Enzyme with a Non-Canonical Organocatalytic Mechanism

Ashleigh Burke – Design and Evolution of an Enzyme with a Non-Canonical Organocatalytic Mechanism