Канал: Open Box Science

[ Alex Chen ] The aged tumor microenvironment limits T cell control of cancer

[ Alex Chen ] The aged tumor microenvironment limits T cell control of cancer

[Sarah Maritan and Miranda Yu] Spatial immune landscapes of primary and metastatic brain tumours

[Sarah Maritan and Miranda Yu] Spatial immune landscapes of primary and metastatic brain tumours

[Priya Devarajan] How are lung cytotoxic CD4 effectors generated during infection?

[Priya Devarajan] How are lung cytotoxic CD4 effectors generated during infection?

[Nadezhda Terekhanova] Epigenetic regulation during cancer transitions across 11 tumour types

[Nadezhda Terekhanova] Epigenetic regulation during cancer transitions across 11 tumour types

[Alon Millet] An exhausted-like microglial population accumulates in aged & APOE4 genotype AD brains

[Alon Millet] An exhausted-like microglial population accumulates in aged & APOE4 genotype AD brains

[Wei Su] CD8 T cells: friend or foe in neurodegeneration

[Wei Su] CD8 T cells: friend or foe in neurodegeneration

[Nicoletta Caronni] IL1beta+ macrophages fuel pathogenic inflammation in pancreatic cancer

[Nicoletta Caronni] IL1beta+ macrophages fuel pathogenic inflammation in pancreatic cancer

What is Polygenic Risk Score? A Primer #prs #genomics

What is Polygenic Risk Score? A Primer #prs #genomics

[Bernhard Sabel] Mass Production of Fake Science Publishing: How Big is the Problem and Why?

[Bernhard Sabel] Mass Production of Fake Science Publishing: How Big is the Problem and Why?

[Meghan Laturney] How the neuroendocrine circuit that regulates sugar feeding in mated females

[Meghan Laturney] How the neuroendocrine circuit that regulates sugar feeding in mated females

[Dana Galili] Parallel representations of position and identity in the olfactory system

[Dana Galili] Parallel representations of position and identity in the olfactory system

[Fran Martínez Jiménez] Unraveling the immunogenics determinants of metastasis across human cancers

[Fran Martínez Jiménez] Unraveling the immunogenics determinants of metastasis across human cancers

[Nathaniel D. Bachtel] Immune sensing of food allergens promotes avoidance behavior

[Nathaniel D. Bachtel] Immune sensing of food allergens promotes avoidance behavior

[Leyuan Ma] Vaccine-boosted car t crosstalk with host immunity to reject tumors with antigen...

[Leyuan Ma] Vaccine-boosted car t crosstalk with host immunity to reject tumors with antigen...

[Olga Zimmermannova] Restoring tumor immunogenicity with dendritic cell reprogramming

[Olga Zimmermannova] Restoring tumor immunogenicity with dendritic cell reprogramming

[Zeribe Nwosu] Uridine-derived ribose fuels glucose-restricted pancreatic cancer

[Zeribe Nwosu] Uridine-derived ribose fuels glucose-restricted pancreatic cancer

[Jesus Corria-Osorio] Orthogonal cytokine engineering enables novel synthetic effector states...

[Jesus Corria-Osorio] Orthogonal cytokine engineering enables novel synthetic effector states...

[Khalid El Bairi] A Focus on Plagiarism and Predatory Publishing

[Khalid El Bairi] A Focus on Plagiarism and Predatory Publishing

[Maria Cecilia Canesso] Dendritic cell-T cell interactions driving immune responses to food

[Maria Cecilia Canesso] Dendritic cell-T cell interactions driving immune responses to food

OBS Immunology: Immune Engineering

OBS Immunology: Immune Engineering

[Jorge Galeano ] 𝗘𝗳𝗲𝗰𝘁𝗼 𝗱𝗲 𝗹𝗮 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝘁𝗮 𝗶𝗻𝘁𝗿𝗮𝘁𝘂𝗺𝗼𝗿𝗮𝗹 𝘀𝗼𝗯𝗿𝗲 𝗹𝗮 𝗵𝗲𝘁𝗲𝗿𝗼𝗴𝗲𝗻𝗲𝗶𝗱𝗮𝗱 𝗲𝘀𝗽𝗮𝗰𝗶𝗮𝗹 d𝗲𝗹 𝗰á𝗻𝗰𝗲𝗿

[Jorge Galeano ] 𝗘𝗳𝗲𝗰𝘁𝗼 𝗱𝗲 𝗹𝗮 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝘁𝗮 𝗶𝗻𝘁𝗿𝗮𝘁𝘂𝗺𝗼𝗿𝗮𝗹 𝘀𝗼𝗯𝗿𝗲 𝗹𝗮 𝗵𝗲𝘁𝗲𝗿𝗼𝗴𝗲𝗻𝗲𝗶𝗱𝗮𝗱 𝗲𝘀𝗽𝗮𝗰𝗶𝗮𝗹 d𝗲𝗹 𝗰á𝗻𝗰𝗲𝗿

[Zoé Christenson Wick] Manipulating single-unit theta phase-locking with PhaSER: An open-source tool

[Zoé Christenson Wick] Manipulating single-unit theta phase-locking with PhaSER: An open-source tool

[Niamh B. McNamara] Microglia regulate central nervous system myelin growth and integrity

[Niamh B. McNamara] Microglia regulate central nervous system myelin growth and integrity

[Sebastiaan de Schepper] Perivascular cells, microglial phagocytosis, synaptic engulfment via SPP1

[Sebastiaan de Schepper] Perivascular cells, microglial phagocytosis, synaptic engulfment via SPP1

[Ángel Álvarez-Prado] Immunogenomic analysis of human brain metastases

[Ángel Álvarez-Prado] Immunogenomic analysis of human brain metastases

[Meng-Tong Li] Gut-brain circuits for fat preference

[Meng-Tong Li] Gut-brain circuits for fat preference

[Reinhard Fischer] How a fungus overcomes the defense of C. elegans

[Reinhard Fischer] How a fungus overcomes the defense of C. elegans

[Hui-Hao Lin] Gut-to-brain communication of nutritional information prioritizes courtship...

[Hui-Hao Lin] Gut-to-brain communication of nutritional information prioritizes courtship...

[Giovanni Quinones-Valdez] Function and Regulation of Nucleotide Variants in RNA

[Giovanni Quinones-Valdez] Function and Regulation of Nucleotide Variants in RNA

[Xin Li] Immune regulation by fungal strain diversity in inflammatory bowel disease

[Xin Li] Immune regulation by fungal strain diversity in inflammatory bowel disease

[Mireia Valles-Colomer] The person-to-person transmission landscape of the gut and oral microbiomes

[Mireia Valles-Colomer] The person-to-person transmission landscape of the gut and oral microbiomes

[Jorge Galeano]Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

[Jorge Galeano]Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

[Takeshi Egawa] Durable CD4 T cell Immunity to persistent antigen by population hierarchy

[Takeshi Egawa] Durable CD4 T cell Immunity to persistent antigen by population hierarchy

[Tuğberk Kaya]CD8+T cells induce IFN-responsive oligodendrocytes and microglia in white matter aging

[Tuğberk Kaya]CD8+T cells induce IFN-responsive oligodendrocytes and microglia in white matter aging

[Synphane Gibbs-Shelton] Microglia play beneficial roles in multiple experimental seizure models

[Synphane Gibbs-Shelton] Microglia play beneficial roles in multiple experimental seizure models

[Christos Lisgaras] Oscillations in Alzheimer's models

[Christos Lisgaras] Oscillations in Alzheimer's models

[Mireia Seuma] An Atlas of Amyloid Aggregation

[Mireia Seuma] An Atlas of Amyloid Aggregation

[Ammar Tareen] MAVE-NN: learning genotype-phenotype maps from MAVE

[Ammar Tareen] MAVE-NN: learning genotype-phenotype maps from MAVE

[Mitchell Fane] Aging promotes reactivation from metastatic melanoma dormancy

[Mitchell Fane] Aging promotes reactivation from metastatic melanoma dormancy

[Lucia Borriello]How does the primary tumor imprint a dormancy signature in disseminated tumor cells

[Lucia Borriello]How does the primary tumor imprint a dormancy signature in disseminated tumor cells

[Margaret L. Axelrod] T cells specific for α-myosin drive immunotherapy-related myocarditis

[Margaret L. Axelrod] T cells specific for α-myosin drive immunotherapy-related myocarditis

[Nataliya Prokhnevska] CD8+ T cell activation in cancer

[Nataliya Prokhnevska] CD8+ T cell activation in cancer

[Patricia Altea Manzano] PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

[Patricia Altea Manzano] PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

[Darshan Sapkota] Neurobiological significance of alternative modes of mRNA translation in astrocyte

[Darshan Sapkota] Neurobiological significance of alternative modes of mRNA translation in astrocyte

[Takuya Osakada] A dedicated hypothalamic oxytocin circuit controls aversive social learning

[Takuya Osakada] A dedicated hypothalamic oxytocin circuit controls aversive social learning

[Junhong Choi] Molecular recording using precision genome editing

[Junhong Choi] Molecular recording using precision genome editing

[Lenka Dohnalova] Ｍicrobiota-derived metabolites regulate motivation for exercise

[Lenka Dohnalova] Ｍicrobiota-derived metabolites regulate motivation for exercise

[Daping Yang] Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production

[Daping Yang] Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production

[Kenichiro Motomura] Fetal and maternal NLRP3 signaling is required for preterm labor and birth

[Kenichiro Motomura] Fetal and maternal NLRP3 signaling is required for preterm labor and birth

[Nuriban Valero-Pacheco] Maternal IL-33 critically regulates tissue remodeling and type 2 immune...

[Nuriban Valero-Pacheco] Maternal IL-33 critically regulates tissue remodeling and type 2 immune...

[John Liao] Neurophysiological basis of stress-induced aversive memory in the nematode C. elegans

[John Liao] Neurophysiological basis of stress-induced aversive memory in the nematode C. elegans

[Sonia Lombroso] Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

[Sonia Lombroso] Engineering an inhibitor-resistant human CSF1R variant for microglia replacement

[Colin YC Lee] A scRNA-seq atlas of immune cells at the CNS borders

[Colin YC Lee] A scRNA-seq atlas of immune cells at the CNS borders

[David Posner] Humoral immunity at the brain borders in homeostasis

[David Posner] Humoral immunity at the brain borders in homeostasis

[Rejane Rua] Meningeal macrophages protect against viral neuroinfection

[Rejane Rua] Meningeal macrophages protect against viral neuroinfection

[Zilin Li] STAARpipeline: a framework for detecting noncoding rare variant associations of WGS study

[Zilin Li] STAARpipeline: a framework for detecting noncoding rare variant associations of WGS study

[Hannah Ennerfelt] SYK coordinates neuroprotective microglial responses in neurodegenerative disease

[Hannah Ennerfelt] SYK coordinates neuroprotective microglial responses in neurodegenerative disease

2022 Open Box Science Awards

2022 Open Box Science Awards

[Carmen Romero-Molina & Francesca Garretti] Microglial efferocytosis: Diving into the Alzheimer's..

[Carmen Romero-Molina & Francesca Garretti] Microglial efferocytosis: Diving into the Alzheimer's..

[Monique L. Smith] Protocols for the social transfer of pain and analgesia in mice

[Monique L. Smith] Protocols for the social transfer of pain and analgesia in mice

[Rune Nguyen Rasmussen] Versatile treadmill system for measuring locomotion and neural activity...

[Rune Nguyen Rasmussen] Versatile treadmill system for measuring locomotion and neural activity...

[Aymeric Silvin] Dual ontogeny of disease associated microglia and disease inflammatory...

[Aymeric Silvin] Dual ontogeny of disease associated microglia and disease inflammatory...

[Phil Ewels] Reproducible bioinformatics for everyone: Nextflow and nf-core

[Phil Ewels] Reproducible bioinformatics for everyone: Nextflow and nf-core

[Lindsay Hayes] Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry

[Lindsay Hayes] Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry

[Chuchu Zhang] Molecular and circuit mechanisms of nausea

[Chuchu Zhang] Molecular and circuit mechanisms of nausea

[Anoj Ilanges] Neural control of the sickness state

[Anoj Ilanges] Neural control of the sickness state

[Jessica Osterhout] The neural basis of sickness

[Jessica Osterhout] The neural basis of sickness

[Ilana Gabanyi] The cross-talk between gut bacteria and neurons

[Ilana Gabanyi] The cross-talk between gut bacteria and neurons

[Brittany Needham] Gut microbial metabolites influence the brain and behavior

[Brittany Needham] Gut microbial metabolites influence the brain and behavior

[Yue Qin] A Multi-scale Map of Cell Structure Fusing Protein Images and Interactions

[Yue Qin] A Multi-scale Map of Cell Structure Fusing Protein Images and Interactions

[Kathy Ayasoufi] Brain resident memory T cells rapidly expand and initiate neuroinflammatory...

[Kathy Ayasoufi] Brain resident memory T cells rapidly expand and initiate neuroinflammatory...

[Miriam Lisci] Mitochondrial translation is required for sustained killing by cytotoxic t cells

[Miriam Lisci] Mitochondrial translation is required for sustained killing by cytotoxic t cells

[Peng Liao] CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

[Peng Liao] CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

[Louai Labanieh] Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

[Louai Labanieh] Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

[Joel Rurik] CAR T cells produced in vivo to treat cardiac injury

[Joel Rurik] CAR T cells produced in vivo to treat cardiac injury

[Lumin Zhou] Reversible CD8 T cell neuron cross-talk causes aging-dependent neuronal regenerative...

[Lumin Zhou] Reversible CD8 T cell neuron cross-talk causes aging-dependent neuronal regenerative...

[Keat Ying Chan] Skin cells undergo asynthetic fission to expand body surfaces in zebrafish.

[Keat Ying Chan] Skin cells undergo asynthetic fission to expand body surfaces in zebrafish.

[Danny Hsu-Shang Te] Cryo-EM analysis of a feline coronavirus spike protein reveals glycans

[Danny Hsu-Shang Te] Cryo-EM analysis of a feline coronavirus spike protein reveals glycans

[Zachary Berndsen] Visualization of the HIV-1 Env glycan shield across scales

[Zachary Berndsen] Visualization of the HIV-1 Env glycan shield across scales

[Tara Tracy] Tau interactome maps synaptic and mitochondrial processes associated with...

[Tara Tracy] Tau interactome maps synaptic and mitochondrial processes associated with...

[Sagar Bapat Obesity alters pathology and treatment response in inflammatory disease

[Sagar Bapat Obesity alters pathology and treatment response in inflammatory disease

[William Reay] Advancing the use of GWAS for drug repurposing and precision treatment

[William Reay] Advancing the use of GWAS for drug repurposing and precision treatment

[Jose Abisambra] Maladaptive translation is tauopathies "Sobre tauopatias y otros demonios"

[Jose Abisambra] Maladaptive translation is tauopathies "Sobre tauopatias y otros demonios"

[Zoeb Jiwaji] Reactive astrocytes acquire neuroprotective as well as deleterious signatures...

[Zoeb Jiwaji] Reactive astrocytes acquire neuroprotective as well as deleterious signatures...

[Brendan Rooney] mTOR controls neurotoxic lysosome exocytosis in inflammatory reactive astrocytes

[Brendan Rooney] mTOR controls neurotoxic lysosome exocytosis in inflammatory reactive astrocytes

[Hugo González Velozo] Cell archetypes in human brain metastases

[Hugo González Velozo] Cell archetypes in human brain metastases

[Beatriz Blanco-Redondo] ALS, from bench to clinic

[Beatriz Blanco-Redondo] ALS, from bench to clinic

[Open Box Science] 2022 Symposium in Science Communication

[Open Box Science] 2022 Symposium in Science Communication

[Johannes Mayer] Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote

[Johannes Mayer] Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote

[Joshua Moreau] Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β

[Joshua Moreau] Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β

[Jonathan Brestoff] Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose...

[Jonathan Brestoff] Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose...

[Michielvan der Vlist] Macrophages transfer mitochondria to sensory neurons to resolve...

[Michielvan der Vlist] Macrophages transfer mitochondria to sensory neurons to resolve...

[Francesco Roselli] IL-13 and its receptor are synaptic proteins involved in plasticity and...

[Francesco Roselli] IL-13 and its receptor are synaptic proteins involved in plasticity and...

[Andrew Yang] A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease...

[Andrew Yang] A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease...

[Rohan Jagirdar] Restoring activity in the thalamic reticular nucleus improves sleep architecture...

[Rohan Jagirdar] Restoring activity in the thalamic reticular nucleus improves sleep architecture...

[Elisa Jentho] Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis

[Elisa Jentho] Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis

[Shing Wan Choi] Tutorial: Polygenic Risk Score (PRS) Analyses

[Shing Wan Choi] Tutorial: Polygenic Risk Score (PRS) Analyses

[Caroline Perner] Protocol for dissection and culture of murine dorsal root ganglia neurons...

[Caroline Perner] Protocol for dissection and culture of murine dorsal root ganglia neurons...

[Evan Bordt] Isolation of Microglia from Mouse or Human Tissue (STAR Protocols 2020)

[Evan Bordt] Isolation of Microglia from Mouse or Human Tissue (STAR Protocols 2020)

[Jorge Domínguez-Andrés] Transmission of trained immunity and heterologous resistance to infections

[Jorge Domínguez-Andrés] Transmission of trained immunity and heterologous resistance to infections

[Jatin Nagpal] Microbiota-brain interactions: Moving toward mechanisms in model organisms

[Jatin Nagpal] Microbiota-brain interactions: Moving toward mechanisms in model organisms

Open Box Science Host Info Session (Oct 14, 2021)

Open Box Science Host Info Session (Oct 14, 2021)

[Ina Stelzer] Vertically transferred maternal immune cells promote neonatal immunity against early

[Ina Stelzer] Vertically transferred maternal immune cells promote neonatal immunity against early

[Ai Ing Lim] Pre-birth Immune Education

[Ai Ing Lim] Pre-birth Immune Education

[María Casanova-Acebes] Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC

[María Casanova-Acebes] Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC

[Online Career Panel] Scientific Editing

[Online Career Panel] Scientific Editing

[Francesca Maria Consonni] Heme catabolism by tumor-associated macrophages controls metastasis

[Francesca Maria Consonni] Heme catabolism by tumor-associated macrophages controls metastasis

[Stefan Berghoff] Microglia facilitate repair of demyelinated lesions via post-squalene sterol...

[Stefan Berghoff] Microglia facilitate repair of demyelinated lesions via post-squalene sterol...

[Garyfallia Gouna] TREM2-dependent lipid droplet biogenesis in phagocytes is required for...

[Garyfallia Gouna] TREM2-dependent lipid droplet biogenesis in phagocytes is required for...

[Amin Sherafat] Microglial neuropilin-1 promotes oligodendrocyte expansion during development and ..

[Amin Sherafat] Microglial neuropilin-1 promotes oligodendrocyte expansion during development and ..

[Georgia Zarkada] Specialized endothelial tip cells guide neuroretina vascularization and......

[Georgia Zarkada] Specialized endothelial tip cells guide neuroretina vascularization and......

[Vanessa Coelho-Santos] Imaging the construction of capillary networks in the neonatal mouse brain

[Vanessa Coelho-Santos] Imaging the construction of capillary networks in the neonatal mouse brain

[Álvaro de Mingo Pulido] The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway

[Álvaro de Mingo Pulido] The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway

[Karen Dixon] TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

[Karen Dixon] TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

[Ryan Flynn] Small RNAs are modified with N-glycans and displayed on the surface of living cells

[Ryan Flynn] Small RNAs are modified with N-glycans and displayed on the surface of living cells

[Gisela Otten] Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection

[Gisela Otten] Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection

[Shima Safaiyan] White matter aging drives microglial diversity (Neuron 2021)

[Shima Safaiyan] White matter aging drives microglial diversity (Neuron 2021)

[Anat Shemer] Interleukin-10 prevents pathological microglia hyperactivation following peripheral...

[Anat Shemer] Interleukin-10 prevents pathological microglia hyperactivation following peripheral...

[Sandro Da Mesquita] Modulation of brain function by meningeal lymphatic drainage in aging and...

[Sandro Da Mesquita] Modulation of brain function by meningeal lymphatic drainage in aging and...

[Carmen Romero Molina] Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease...

[Carmen Romero Molina] Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease...

[Felix Pahmeier] A Versatile Reporter System To Monitor Virus-Infected Cells and Its Application..

[Felix Pahmeier] A Versatile Reporter System To Monitor Virus-Infected Cells and Its Application..

[Ryan Flynn] Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

[Ryan Flynn] Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

[Yulong Xu] Molecular imaging of #Alzheimer's disease-related gamma-secretase in mice and nonhuman..

[Yulong Xu] Molecular imaging of #Alzheimer's disease-related gamma-secretase in mice and nonhuman..

[Clarissa Cooley] A portable scanner for magnetic resonance imaging of the brain

[Clarissa Cooley] A portable scanner for magnetic resonance imaging of the brain

[Nicola Fattorelli] Stem-cell-derived human microglia transplanted into mouse brain to study human..

[Nicola Fattorelli] Stem-cell-derived human microglia transplanted into mouse brain to study human..

[Anastasie Maté de Gérando] Neuronal tau species transfer to astrocytes and induce their loss...

[Anastasie Maté de Gérando] Neuronal tau species transfer to astrocytes and induce their loss...

[William Meilandt] Trem2 restrains the enhancement of tau accumulation and neurodegeneration...

[William Meilandt] Trem2 restrains the enhancement of tau accumulation and neurodegeneration...

[Christine Rother] Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-...

[Christine Rother] Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-...

[Jr-Jiun "Jean" Liou] Effect of Platelet-Rich Plasma on Chondrogenic Differentiation of Adipose...

[Jr-Jiun "Jean" Liou] Effect of Platelet-Rich Plasma on Chondrogenic Differentiation of Adipose...

[Alexey Stukalov] Multiomics analysis of SARS-COV-2 and SARS-CoV

[Alexey Stukalov] Multiomics analysis of SARS-COV-2 and SARS-CoV

[Toni Delorey] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

[Toni Delorey] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

[Matthew Spitzer] Systemic Immunity in Cancer

[Matthew Spitzer] Systemic Immunity in Cancer

[Kuan-lin Huang] Spatially interacting phosphorylation sites and mutations in cancer

[Kuan-lin Huang] Spatially interacting phosphorylation sites and mutations in cancer

[Leah Cuddy] Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q...

[Leah Cuddy] Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q...

[Selene Lomoio] Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease

[Selene Lomoio] Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease

[Sergio Quezada] CD25-T reg-depleting antibodies preserving IL-2 signaling on effector T cells..

[Sergio Quezada] CD25-T reg-depleting antibodies preserving IL-2 signaling on effector T cells..

[Greg Delgoffe] Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

[Greg Delgoffe] Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

[Karsten Suhre] Genetics meets proteomics: perspectives for large population-based studies

[Karsten Suhre] Genetics meets proteomics: perspectives for large population-based studies

[Aude Chiot] Modifying macrophages at the periphery has the capacity to change microglial reactivity

[Aude Chiot] Modifying macrophages at the periphery has the capacity to change microglial reactivity

[Paras Minhas] Restoring metabolism of myeloid cells reverses cognitive decline in ageing

[Paras Minhas] Restoring metabolism of myeloid cells reverses cognitive decline in ageing

[Joana P. Bernardes & Neha Mishra] Longitudinal Multi-omics Identify Hallmarks of Severe COVID-19

[Joana P. Bernardes & Neha Mishra] Longitudinal Multi-omics Identify Hallmarks of Severe COVID-19

[Takehiro Takahashi] Sex differences in immune responses that underlie COVID-19 disease outcomes

[Takehiro Takahashi] Sex differences in immune responses that underlie COVID-19 disease outcomes

[Marc Jan Bonder & Craig Smail] Identification of rare and common regulatory variants in iPSCs

[Marc Jan Bonder & Craig Smail] Identification of rare and common regulatory variants in iPSCs

[Julia Zeitlinger] Base-resolution models of transcription-factor binding reveal soft motif syntax

[Julia Zeitlinger] Base-resolution models of transcription-factor binding reveal soft motif syntax

[Kevin Litchfield] Meta-analysis of tumor/T cell-intrinsic sensitization to checkpoint inhibition

[Kevin Litchfield] Meta-analysis of tumor/T cell-intrinsic sensitization to checkpoint inhibition

[David Vredevoogd] Augmenting immunotherapy impact by lowering tumor TNF cytotoxicity threshold

[David Vredevoogd] Augmenting immunotherapy impact by lowering tumor TNF cytotoxicity threshold

[Maria Gutierrez-Arcelus] Allele-specific expression changes dynamically during T cell activation

[Maria Gutierrez-Arcelus] Allele-specific expression changes dynamically during T cell activation

[Chang Hoon Lee] Profiling allele-specific gene expression in autism spectrum disorder

[Chang Hoon Lee] Profiling allele-specific gene expression in autism spectrum disorder

[Eric Van Nostrand] A large-scale binding and functional map of human RNA-binding proteins

[Eric Van Nostrand] A large-scale binding and functional map of human RNA-binding proteins

[Daniel Cui Zhou] Single cell analyses of pancreatic cancer & HTAN

[Daniel Cui Zhou] Single cell analyses of pancreatic cancer & HTAN

[Liang-Bo Wang] Building insights toward proteogenomic characterization of glioblastoma tumors

[Liang-Bo Wang] Building insights toward proteogenomic characterization of glioblastoma tumors

[Peter Jin] Sequencing implicates genetic disruption of prenatal neuro-gliogenesis in hydrocephalus

[Peter Jin] Sequencing implicates genetic disruption of prenatal neuro-gliogenesis in hydrocephalus

[Step-by-Step] How to set-up your zoom meetings to prevent trolls?

[Step-by-Step] How to set-up your zoom meetings to prevent trolls?

[Jing Zhang] Using ENCODE Data for Disease Genome Mining

[Jing Zhang] Using ENCODE Data for Disease Genome Mining

[Online Career Panel] Consulting in Biomedicine

[Online Career Panel] Consulting in Biomedicine

[Jonas Schluter] The gut microbiota is associated with immune cell dynamics in humans

[Jonas Schluter] The gut microbiota is associated with immune cell dynamics in humans

[Naama Geva-Zatorsky] Mining the Human Gut Microbiota for Immunomodulatory Organisms

[Naama Geva-Zatorsky] Mining the Human Gut Microbiota for Immunomodulatory Organisms

[Andrew Sas] A new neutrophil subset promotes CNS neuron survival and axon regeneration

[Andrew Sas] A new neutrophil subset promotes CNS neuron survival and axon regeneration

[Ioannis Kourtzelis] Innate immune training of granulopoiesis promotes anti-tumor activity

[Ioannis Kourtzelis] Innate immune training of granulopoiesis promotes anti-tumor activity

[Minsoo Kim] In situ neutrophil efferocytosis shapes T cell immunity to influenza infection

[Minsoo Kim] In situ neutrophil efferocytosis shapes T cell immunity to influenza infection

[Ivan Ballesteros Martin] Co-option of Neutrophil Fates by Tissue Environments

[Ivan Ballesteros Martin] Co-option of Neutrophil Fates by Tissue Environments

[Rod Rahimi] Distinct functions of tissue-resident and circulatingmemory Th2 cells in allergic...

[Rod Rahimi] Distinct functions of tissue-resident and circulatingmemory Th2 cells in allergic...

[Caroline L Sokol] Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and...

[Caroline L Sokol] Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and...

[Amanda C. Poholek] Blimp-1 is essential for allergen-induced asthma and Th2 cell development in ...

[Amanda C. Poholek] Blimp-1 is essential for allergen-induced asthma and Th2 cell development in ...

Open Box Science Host Info Session (Dec 2020)

Open Box Science Host Info Session (Dec 2020)

[Online Career Panel] What’s it like to work in Biotech?

[Online Career Panel] What’s it like to work in Biotech?

[Jesuthas Ajendra] IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2...

[Jesuthas Ajendra] IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2...

[Juan Inclan Rico] Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated...

[Juan Inclan Rico] Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated...

[Tiffany Bouchery] Hookworms evade host Immunity by secreating a DNAse II to degrade neutrophil

[Tiffany Bouchery] Hookworms evade host Immunity by secreating a DNAse II to degrade neutrophil

[Caroline Jansen] An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

[Caroline Jansen] An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

[Anthony Umpierre] Microglial calcium signaling is attuned to neuronal activity in awake mice

[Anthony Umpierre] Microglial calcium signaling is attuned to neuronal activity in awake mice

[Ana Badimon] Negative feedback control of neuronal activity by microglia

[Ana Badimon] Negative feedback control of neuronal activity by microglia

[Lucas Cheadle] Sensory Experience Engages Microglia to Shape Neural Connectivity

[Lucas Cheadle] Sensory Experience Engages Microglia to Shape Neural Connectivity

[Ashley Nemes-Baran] Fractalkine-Dependent Microglial Pruning of Viable OPCs Regulates Myelination

[Ashley Nemes-Baran] Fractalkine-Dependent Microglial Pruning of Viable OPCs Regulates Myelination

[Ashley Nemes-Baran] Fractalkine-Dependent Microglial Pruning of Viable OPCs Regulates Myelination

[Ashley Nemes-Baran] Fractalkine-Dependent Microglial Pruning of Viable OPCs Regulates Myelination

[Meng-Meng Fu ]The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination

[Meng-Meng Fu ]The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination

[Wei-Ting Chen] Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease

[Wei-Ting Chen] Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease

[Gracie Liu] University of Pittsburgh Neuropilin-1 is a T cell memory checkpoint limiting long-term

[Gracie Liu] University of Pittsburgh Neuropilin-1 is a T cell memory checkpoint limiting long-term

[Nandini Acharya] Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and ...

[Nandini Acharya] Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and ...

[Gaia Di Timoteo]Modulation of circRNA Metabolism by m6A Modification

[Gaia Di Timoteo]Modulation of circRNA Metabolism by m6A Modification

[Ye Grace Chan] N6-Methyladenosine Modification Controls Circular RNA Immunity

[Ye Grace Chan] N6-Methyladenosine Modification Controls Circular RNA Immunity

[Tommaso Villa] Degradation of Non-coding RNAs Promotes Recycling

[Tommaso Villa] Degradation of Non-coding RNAs Promotes Recycling

[Carina Weigelt] An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

[Carina Weigelt] An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

[Matthew Holt] Molecular heterogeneity of astrocytes: implications for development and function

[Matthew Holt] Molecular heterogeneity of astrocytes: implications for development and function

[Anna Yu-Szu Huang] Region-specific transcriptional control of astrocyte function

[Anna Yu-Szu Huang] Region-specific transcriptional control of astrocyte function

[Kevin Guttenplan] Neurotoxic Reactive Astrocytes in mouse models of Retinal Injury and ALS

[Kevin Guttenplan] Neurotoxic Reactive Astrocytes in mouse models of Retinal Injury and ALS

[Adi Kol] Astrocytes contribute to remote memory formation during learning

[Adi Kol] Astrocytes contribute to remote memory formation during learning

[David Hildeman] IL-10producing Tfh cells accumulate with age and link inflammation with age-related

[David Hildeman] IL-10producing Tfh cells accumulate with age and link inflammation with age-related

Open Box Science Symposium Chair Info Session (09/10/20)

Open Box Science Symposium Chair Info Session (09/10/20)

[Stephanie Eisenbarth] Divergent T follicular helper cell requirement for IgA and IgE...

[Stephanie Eisenbarth] Divergent T follicular helper cell requirement for IgA and IgE...

[Shane Crotty] Bcl-6 is the nexus transcription factor of Tfh cells via repressor-of-...

[Shane Crotty] Bcl-6 is the nexus transcription factor of Tfh cells via repressor-of-...

Divij Mathew (UP) Deep immune profiling of COVID-19 patients reveals distinct immunotypes with..

Divij Mathew (UP) Deep immune profiling of COVID-19 patients reveals distinct immunotypes with..

[Achille Broggi ] Type III interferons disrupt the lung epithelial barrier upon viral recogniti

[Achille Broggi ] Type III interferons disrupt the lung epithelial barrier upon viral recogniti

[Jack Major ] Type I and III interferons disrupt lung epithelial repair during recovery

[Jack Major ] Type I and III interferons disrupt lung epithelial repair during recovery

[Emanuela Pasciuto]Microglia require CD4 T cells to complete the fetal-to-adult transition

[Emanuela Pasciuto]Microglia require CD4 T cells to complete the fetal-to-adult transition

[Alexandria Hughes] Microglia phagocytose myelin sheaths to modify developmental myelination

[Alexandria Hughes] Microglia phagocytose myelin sheaths to modify developmental myelination

[Catherine Lammert] AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

[Catherine Lammert] AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

[Justin Milner] Heterogenous Populations of Tissue Resident CD8 T Cells Are Generated in Response

[Justin Milner] Heterogenous Populations of Tissue Resident CD8 T Cells Are Generated in Response

[Stina Urban] Peripherally induced brain Trm CD8 T cells mediate protection against CNS infection

[Stina Urban] Peripherally induced brain Trm CD8 T cells mediate protection against CNS infection

[Henrique Borges da Silva] Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8

[Henrique Borges da Silva] Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8