Канал: 4D Nucleome

Perturb-tracing enables scalable high-content discovery of 3D genome regulators

Perturb-tracing enables scalable high-content discovery of 3D genome regulators

m6A-MAPT-uaRNA regulates gene expression in Alzheimer’s disease

m6A-MAPT-uaRNA regulates gene expression in Alzheimer’s disease

Multiplexed mapping of the 3D organization of regulatory proteins within the nucleus

Multiplexed mapping of the 3D organization of regulatory proteins within the nucleus

Mapping complex cell fate dynamics using cell phylogeny

Mapping complex cell fate dynamics using cell phylogeny

Quantitative control of Ets1 dosage by a multi-enhancer hub is required for T cell function

Quantitative control of Ets1 dosage by a multi-enhancer hub is required for T cell function

Genomics Visualization on WashU Epigenome Browser

Genomics Visualization on WashU Epigenome Browser

Population-based modeling unveils functional details of chromatin 3D organization

Population-based modeling unveils functional details of chromatin 3D organization

GOLD FISH: a novel chromatin imaging method to study spatiotemporal features of nuclear biology

GOLD FISH: a novel chromatin imaging method to study spatiotemporal features of nuclear biology

Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization

Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization

Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation

Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation

Boundary stacking interactions enable cross-TAD enhancer-promoter communication during limb developm

Boundary stacking interactions enable cross-TAD enhancer-promoter communication during limb developm

Chromosomes as epigenetic memory machines

Chromosomes as epigenetic memory machines

Image-based sorting of mouse embryo-derived nuclei

Image-based sorting of mouse embryo-derived nuclei

“Multimodal Visualization for 4DN data using Nucleome Browser and OME”

“Multimodal Visualization for 4DN data using Nucleome Browser and OME”

The 4DN Data Portal

The 4DN Data Portal

Nested Enhancer Epistasis Networks Link Multiple Non-coding Variants to Disease Risk

Nested Enhancer Epistasis Networks Link Multiple Non-coding Variants to Disease Risk

A spatial genome aligner for multiplexed DNA-FISH

A spatial genome aligner for multiplexed DNA-FISH

A convolutional neural network predicts chromatin contact frequency and regulatory consequences

A convolutional neural network predicts chromatin contact frequency and regulatory consequences

Probing the mechanism and function of the 3D genome

Probing the mechanism and function of the 3D genome

GraphReg: chromatin interaction aware gene regulatory modeling with graph attention networks

GraphReg: chromatin interaction aware gene regulatory modeling with graph attention networks

“Topological Operons: Transcriptional Coupling of Distant Regulatory Genes in Living Embryos”

“Topological Operons: Transcriptional Coupling of Distant Regulatory Genes in Living Embryos”

HiGlass Visualization in the 4DN Data Portal

HiGlass Visualization in the 4DN Data Portal

Dissecting chromatin remodeler-modified oligonucleosome patterns in vitro and in vivo with single

Dissecting chromatin remodeler-modified oligonucleosome patterns in vitro and in vivo with single

Stripenn detects architectural stripes from chromatin conformation data using computer vision

Stripenn detects architectural stripes from chromatin conformation data using computer vision

Multiscale and integrative single-cell Hi-C analysis

Multiscale and integrative single-cell Hi-C analysis

Cell-type specialization in the brain is encoded by specific long-range chromatin topologies

Cell-type specialization in the brain is encoded by specific long-range chromatin topologies

Why do only rare somatic cells reprogram into induced pluripotent stem cells?

Why do only rare somatic cells reprogram into induced pluripotent stem cells?

Relationships between genome editing and epigenetic states revealed by multiplexed CRISPR

Relationships between genome editing and epigenetic states revealed by multiplexed CRISPR

Stress-induced RNA–chromatin interactions promote endothelial dysfunction

Stress-induced RNA–chromatin interactions promote endothelial dysfunction

Projection Analysis for Transfer Learning across Experimental Modalities

Projection Analysis for Transfer Learning across Experimental Modalities

Analysis of cis-regulatory chromatin contacts anchored on open DNA sequences by HiCAR

Analysis of cis-regulatory chromatin contacts anchored on open DNA sequences by HiCAR

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

2.5D microscopy: Fast, high-throughput imaging via volumetric projection

2.5D microscopy: Fast, high-throughput imaging via volumetric projection

Micro-Meta App: to facilitate collection of 4DN-BINA-OME compliant Microscopy Metadata

Micro-Meta App: to facilitate collection of 4DN-BINA-OME compliant Microscopy Metadata

Tutorial for 4DN new members: Tools and services provided by 4DN OH

Tutorial for 4DN new members: Tools and services provided by 4DN OH

4DN Phase 2 Onboarding

4DN Phase 2 Onboarding

Community driven Minimum Information Guidelines for light microscopy

Community driven Minimum Information Guidelines for light microscopy

A study on effects of fixation with Formaldehyde and Paraformaldehyde

A study on effects of fixation with Formaldehyde and Paraformaldehyde

CUT&RUN and CUT&Tag methods for profiling chromatin marks and chromatin structure

CUT&RUN and CUT&Tag methods for profiling chromatin marks and chromatin structure

Cryo-Milling TCC-Based Mapping of Genome-Wide Chromatin Contacts

Cryo-Milling TCC-Based Mapping of Genome-Wide Chromatin Contacts

WashU Epigenome Browser: Engaging ENCODE, Roadmap Epigenomics, and 4DN

WashU Epigenome Browser: Engaging ENCODE, Roadmap Epigenomics, and 4DN

WashU Epigenome Browser: Hands on demo

WashU Epigenome Browser: Hands on demo

Transcriptionally Active HERV-H Retrotransposons Demarcate TADs in Human ESCs

Transcriptionally Active HERV-H Retrotransposons Demarcate TADs in Human ESCs

Studying the structural organization of subnuclear chromatin compartments

Studying the structural organization of subnuclear chromatin compartments

The composition and regulation of nucleolus-associated domains

The composition and regulation of nucleolus-associated domains

Pairing enhancers with their target genes via multiplexed cellular genetic screens

Pairing enhancers with their target genes via multiplexed cellular genetic screens

Co-opted transposons help perpetuate conserved higher-order chromosomal structures

Co-opted transposons help perpetuate conserved higher-order chromosomal structures

Reproducible Data Processing at the 4DN Data Coordination and Integration Center

Reproducible Data Processing at the 4DN Data Coordination and Integration Center

Nuclear pores as versatile reference standards for quantitative microscopy

Nuclear pores as versatile reference standards for quantitative microscopy

CRISPR Live Cell imaging (CLING) and HiC data: insights into CTCF, RNA and TAD Boundaries

CRISPR Live Cell imaging (CLING) and HiC data: insights into CTCF, RNA and TAD Boundaries

Heterochromatin drives organization of conventional and inverted nuclei

Heterochromatin drives organization of conventional and inverted nuclei

Neutrophil genome dynamics in development and pathogen encounter

Neutrophil genome dynamics in development and pathogen encounter

The p53 transcription factor regulation on the p21 gene locus

The p53 transcription factor regulation on the p21 gene locus

Trac-looping: a novel technique for analysis of chromatin accessibility and interaction

Trac-looping: a novel technique for analysis of chromatin accessibility and interaction

Interacting differentially methylated regions (iDMRs) to infer chromosome looping

Interacting differentially methylated regions (iDMRs) to infer chromosome looping

Elucidating the role of nascent RNA at enhancers

Elucidating the role of nascent RNA at enhancers

CUT&RUN: Efficient genome-wide profiling of the epigenomic landscape

CUT&RUN: Efficient genome-wide profiling of the epigenomic landscape

Looking beyond pairwise 3D conformation of the genome by MC-4C

Looking beyond pairwise 3D conformation of the genome by MC-4C

How the Genome Awakens in Zebrafish

How the Genome Awakens in Zebrafish

Dynamics of Genome Reorganization during Human Cardiogenesis

Dynamics of Genome Reorganization during Human Cardiogenesis

Frequency modulation of polymerase recruitment via transcriptional bursting

Frequency modulation of polymerase recruitment via transcriptional bursting

Mapping genome 3D structure by direct DNA-DNA photo-crosslinking and click enrichment

Mapping genome 3D structure by direct DNA-DNA photo-crosslinking and click enrichment

Developing a new framework to detect and link protein complexes to specific chromatin interactions

Developing a new framework to detect and link protein complexes to specific chromatin interactions

4DN Imaging Workshop: Toward Microscopy Standardization

4DN Imaging Workshop: Toward Microscopy Standardization