Our treatment specialist and founder of ATMC, Lyle Murphy, answers your biggest concerns about the antipsychotic drug Rexulti (Brexpiprazole).
Q&A From you!
00:00 - Intro
00:22 - How are atypical antipsychotics like Rexulti different from other atypicals such as Seroquel and Zyprexa?
03:31 - What dopaminergic pathway is effected by Rexulti?
04:18 - Can you stop Rexulti cold turkey?
05:42 - How long does it take before you get addicted to Rexulti?
06:36 - The doctor prescribed me Sinequan 50mg, Rexulti 0.5 mg, and PMs-Duloxetine 60mg. Should I be concerned about raised sugar levels as I'm diabetic.
07:20 - How long does it take to withdraw off of Rexulti, 1 mg taken for two weeks?
09:55 - Is there a scenario for you to be prescribed rexulti and tentrellix together?
11:36 - Does stiff hand muscles caused by Rexulti fade with time as the body builds up tolerance against the medication?
12:45 - Why wasn't Rexulti approved for ADHD?
13:55 - How is Rexulti different from Abilify?
16:50 - Is it worth it to take try Rexulti if there was limited success with Abilify? It's supposed to be an improved version.
17:51 - How does a dopamine partial agonist like Rexulti interact with stimulants like Ritalin?
19:13 - Have you have seen good experiences taking Rexulti for depression? Is it safer than most?
20:48 - Can someone with trauma and psychosis still channel and be clairvoyant if they are taking Rexulti and Seroquel?
22:36 - How can the psychiatric drug Rexulti cost about 50% of the typical monthly income of a new employee in the US food industry, like the young woman shown in their commercial?
24:23 - ATMC
How Does Rexulti Work?
Rexulti works in the brain by balancing chemicals. More specifically, it is a serotonin-dopamine activity modulator (SDAM) that works with the dopamine and serotonin receptors inside the brain. Serotonin and dopamine are important neurotransmitters that nerve cells release and receptors in the brain pick up. Both serotonin and dopamine play a role in depression, but each works a little differently.
Dopamine Is a Motivator
Increasing dopamine may help with some depression symptoms, including low motivation, a loss of interest in things that used to be enjoyable, and thoughts of helplessness. This is because dopamine is the motivation and reward chemical. It’s why you get a rush when you complete a task. Dopamine helps people enjoy all kinds of activities. From food to sex, dopamine being released in the brain helps us enjoy those experiences. Unfortunately, it’s also what leads to addictions, including drugs, gambling, and shopping.
Dopamine Can Cause Problems for Users
Dopamine does not always get released at the same level. An activity that once brought a rush to a person may not be as exciting after a while. This means that a person may “use” more than they once did to get the same rush, whether it is a drug or another addiction. Dopamine dysfunction has been tied to bipolar disorder, major depressive disorder, attention deficit hyperactivity disorder (ADHD), and schizophrenia.
Rexulti Moderates Serotonin Activity Too
Serotonin can affect a person’s overall mood because serotonin helps a person process their emotions. Low serotonin levels were thought to be the cause of depression, but several decades of research have suggested that it is not quite that simple. The most effective non-holistic medicinal approach to depression is to increase serotonin levels in the brain by using selective serotonin reuptake inhibitors (SSRIs). Forty to 60 percent of people with moderate to severe depression who start SSRIs feel they are improving within six to eight weeks. That leaves a lot of patients not responding to the SSRIs. That’s why doctors may prescribe Rexulti (brexpiprazole) in addition to an SSRI for major depressive disorder.
Increased serotonin in the brain does not always equate to less depression. Instead, increased serotonin helps with positive emotional processing. Over time, that can result in an overall improvement in mood.
Serotonin has been linked to autism spectrum disorders, bipolar disorder, anxiety disorders, obsessive-compulsive disorder (OCD), and social anxiety disorder.
Not only do serotonin and dopamine affect a person’s mood, they can also affect a person’s sleep and digestion.
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