Try to stay away from the NW patches of Spice, as this seems to aggravate the Harkonnen, and they now have their Devastator Tanks, but you have a reasonable starting force that when backed up with a few Missile Turrets will deal with most attacking threats.
The Ordos enemies didn't seem to attack much thankfully, but I thought I'd be best off with solid defenses. I think the NE field triggered them. So stick to the SW field as much as you can until you're defended.

I attack the Harkonnen first, because their Death Hand (nuke) ability, and Devastators are more of a threat.
Get a reasonable sized force of Missile Tanks/Sonic Tanks backed up by Siege Tanks and you should do fine.
I had more problems with Ordos, but mainly I think because of the credits they had amassed, which gave them annoyingly quick repairs.

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