Cameron Poe, a highly decorated Army Ranger, comes home to Alabama to his wife Tricia, only to run into a few drunken regulars at the bar where she works. Cameron accidentally kills one of the drunks, and is sent to a federal penitentiary for involuntary manslaughter for seven years. He becomes eligible for parole and can now go home to his wife and daughter. Unfortunately, Cameron has to share a prison airplane with some of the country's most dangerous criminals, who take control of the plane and are now planning to escape the country. Cameron has to find a way to stop them while playing along. Meanwhile, United States Marshal Vince Larkin is trying to help Cameron get free and stop the criminals, led by Cyrus "The Virus" Grissom.

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