Why does adenine sometimes pair with cytosine? HOW could that happen? Well, sometimes nucleobases (bases) misbehave, which leads to a lot of confusion for students (and often a mutation in the complementary strand!) It's called tautomerization, and I'll break it all down PenguinProf style!
#biology #DNA #mutation #tautomerization
This video covers:
What are constitutional (structural) isomers? Examples, analogy.
What are tautomers? Examples, analogy.
What is a tautomeric shift?
What happens when nucleobases (bases) undergo a tautomeric shift?
What are the typical and atypical base pairings? With structures.
Next, I'll use a small strand of DNA and watch it go through 2 replications, transcription and translation after a tautomeric shift.
So is a tautomeric shift in and of itself a mutation? Why or why not?
Summary.
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Gear:
Computer: iMac 27" late 2015
Mic: Apogee Hypermic
Software: Keynote, ScreenFlow, ChemDraw
Organic Chemistry consultant: FabioChem
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