It’s a well-known fact, that seizures result in memory loss and other cognitive deficits in patients with Alzheimer’s disease, but how this happens was not clear. A better understanding of this new mechanism may lead to future strategies to reduce cognitive deficits in Alzheimer’s disease and memory loss associated with epilepsy. It’s been hard to understand how infrequent seizures can lead to persistent changes in memory in patients with Alzheimer’s disease. To solve this puzzle, the researchers studied on Alzheimer’s disease models, focusing on the genetic changes that seizures might trigger in the hippocampus, the memory center of the brain, that could lead to loss of memory or other cognitive deficits. They measured the levels of proteins involved in memory and learning and found that levels of the protein deltaFosB is strikingly increased in the hippocampus of Alzheimer’s disease, that had seizures. DeltaFosB is a protein associated with many neurological conditions linked to persistent brain activity of specific brain regions, involved in addiction.
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