Title:

What are the major genes responsible for inherited susceptibility to the common cancers?

Presenters:

1. William D Foulkes MBBS PhD FRCPC
Member, Division of Medical Genetics, MUHC

2. Jean-Baptiste Rivière, PhD, FCCMG
Molecular geneticist at the MUHC


Dr.William Foulkes is a Senior Scientist at RI-MUHC, Cancer Research Program
Centre for Translational Biology, a Professor at Department of Medicine, Faculty of Medicine and Health Sciences, McGill University as well as Department of Medicine, Division of Medical Genetics, MUHC.

His research focuses on inherited predisposition to cancer. Throughout his career, he has worked to discover the genetic lesions predisposing to cancer development in families where clustering of certain cancer types is observed.

Over the years, he has studied genes predisposing to the cancer of the breast, colon, ovary and prostate.

Furthermore, he is currently investigating the mechanism by which inherited mutations in the gene DICER1 predispose infants to develop a range of rare tumours, such as pleuropulmonary blastoma, pituitary blastoma or cystic nephroma, early in their life, and he oversees a Registry & Biobank that collects samples and data to support research on the rare small cell carcinoma of the ovary, hypercalcemic type.

As a researcher-clinician, it is his belief that advances in understanding genetic predisposition to cancer will result in improved prevention and treatment options for our patients and their families.
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Jean-Baptiste Rivière is an assistant professor at McGill's Department of Human Genetics, a clinical molecular geneticist at the MUHC, an associate investigator at the RI-MUHC and the Scientific Director of the RI-MUHC Bioinformatics Platform. He is specialized in identifying genetic alterations responsible for genetic diseases using next-generation sequencing (NGS) and associated bioinformatics tools, and translating genomic technologies into clinical practice, both for rare diseases and cancer.
His current publications list can be viewed here:

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