Dr. Clarke discusses their recent minireview published in the March 2021 issue of Neurogastroenterology and Motility Journal.
Wilmes L, Collins JM, O'Riordan KJ, O'Mahony SM, Cryan JF, Clarke G. Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome. Neurogastroenterol Motil. 2021 Mar;33(3):e14095. doi: 10.1111/nmo.14095. Epub 2021 Feb 13. PMID: 33580895.
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Dr. Gerard Clarke is a lecturer in the Department of Psychiatry and Neurobehavioural Science and a Principal Investigator in APC Microbiome Ireland at University College Cork. His research interests include the impact of the gut microbiome on brain and behaviour across the life span, microbial regulation of tryptophan metabolism and translational biomarkers of stress-related neuropsychiatric disorders. His research has been recognised internationally by travel awards from the European College of Neuropsychopharmacology (ECNP) as well as a prestigious career development award from the American Neurogastroenterology and Motility Society (ANMS) and a NARSAD award from the Brain and Behaviour Research Foundation. He is a partner in the H2020 DISCOvERIE consortium leading a project focused on understanding the role of the gut microbiota in psychiatric comorbidity in irritable bowel syndrome.
In this review they highlight compositional changes in gut bacteria associated with gut‐brain axis signaling pathways and the specific pathways by which gut bacteria can influence mood disorders. They also discuss a study published in the same issue of neurogastroenterology and motility journal where authors show S. boulardii CNCM I‐745 improves anxiety‐like behavior in an IBS‐microbiota humanized mouse model through modulation of pain pathways and indole production.
Constante M, De Palma G, Lu J, Jury J, Rondeau L, Caminero A, Collins SM, Verdu EF, Bercik P. Saccharomyces boulardii CNCM I-745 modulates the microbiota-gut-brain axis in a humanized mouse model of Irritable Bowel Syndrome. Neurogastroenterol Motil. 2021 Mar;33(3):e13985. doi: 10.1111/nmo.13985. Epub 2020 Sep 21. PMID: 32955166.
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