The Perforin Granzyme Pathway is a series of immune reactions driven by Cytotoxic T-Cell in Infected/Cancerous cells with which the target cell is finally eliminated.This process initiates a process called Apoptosis by which programmed cell death occurs.This is different from FAS Pathway in way that it does not require any ligand to kick start a reaction that is why Perforin Granzyme Pathway is called Intrinsic pathway for Apoptosis.The whole mechanism has been shown in this video and i hope you will learn from this.
Cytochrome C release from Mitochondria is not in detail here but for that a separate video will be made. Thanks and do subscribe to this channel.
Mechanism of Perforin Granzyme Pathway
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Perforin Granzyme PathwayGranzyme PathwayPerforin PathwayMechanism of Perforin Granzyme Pathwayapoptosisctl mediated toxicitycytotoxic T cellcytotoxic t cell mediated toxicityintrinsic apoptosis pathwayintrinsic apoptosisintrinsic pathway of apoptosiscytochrome c apoptosisAPAF apoptosisCaspase 3 apoptosisBAX apoptosismitochondrial apoptosis