Levofloxacin (fluoroquinolone antibiotic): Levofloxacin is a fluoroquinolone antibiotic available for oral or intravenous administration. Levofloxacin is the optically active L-isomer of ofloxacin. It has a slightly longer half-life than ofloxacin and can be administered once daily. Levofloxacin is more active than ofloxacin against staphylococci and streptococci.
Levofloxacin is FDA approved for the treatment of sinusitis, chronic bronchitis, community-acquired pneumonia, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. Its tablets and injection were FDA approved for the treatment of these infections on 12/20/96. It inhibits bacterial DNA gyrase, a type II topoisomerase. Topoisomerases alter DNA by introducing superhelical twists into double-stranded DNA and by facilitating the unwinding of DNA strands.
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