How does Paget's disease of the breast present? What is the differential diagnosis of Paget's disease and how is it diagnosed? The most useful stains are CK7 and HER2. Examples of Paget's disease are included with gross and histological images. Cells that can be confused for Paget cells are Toker cells. pictures of these and relevant immuno (CK7 and HER2) are included.
Many thanks to Dr Zsolt Hodi for the images of Toker cells.
0:10 Sir James Paget, presentation, age of Paget's disease
0:50 Gross appearance of Paget's disease
1:06 Paget's disease and DCIS and invasive breast cancer
1:45 Histological appearance of Paget's disease
2:12 Diagnosing Paget's disease
2:50 Immuno stains for Paget's disease
3:15 H&E of Paget's disease
3:36 CK7 stain for Paget's disease
3:50 HER2 stain for Paget's
4:07 Differentail diagnosis of Paget's disease
4:35 What are Toker cells?
5:20 Toker cells H&E photo
5:58 Toker cells CK7 positive
6:40 Toker cells HER2 negative

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