The only way to successfully treat sepsis caused by S. aureus. When dealing with infections caused by S.aureus, everything has to be done right: The choice of antibiotics, the duration of treatment, screening for complications like endocarditis and metastatic infections, source control, follow-up blood cultures, and much more. Even with modern drugs, Staphylococcus aureus bacteremia still carries a mortality rate of 25%, but there is a lot we can do to increase our patients' chances.
If you want to make sure you recognize life-threatening infections like sepsis and CNS infections in time, you will find invaluable tips in my short, practice-oriented lectures!

A Clinical Approach to Serious Infections in Adults: What Every Physician Should Know:
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DISCLAIMER: Please, always keep in mind that my videos are intended for educational purposes only. The content of my videos is NOT medical advice. I do not practice medicine over the internet. If you are a patient and have any questions about your health, please talk to your doctor.

CHAPTERS:
00:00 What makes S. aureus special
01:49 Empiric and definitive therapy for S.aureus (MRSA vs. MSSA)
04:09 Blood cultures and other microbiological samples
05:14 What antibiotics are best for MSSA
05:52 The duration of treatment
06:28 Look for endocarditis and removable foci of infection
07:59 The final tip

REFERENCES & RECOMMENDED READING:
1. Lam JC, Stokes W. The Golden Grapes of Wrath - Staphylococcus aureus Bacteremia: A Clinical Review. Am J Med. 2023 Jan;136(1):19–26.
2. Heffernan AJ, Sime FB, Lim SMS, Adiraju S, Wallis SC, Lipman J, et al. Pharmacodynamics of ceftriaxone for the treatment of methicillin-susceptible Staphylococcus aureus: is it a viable treatment option? Int J Antimicrob Agents. 2022 Mar;59(3):106537.
3. McDanel JS, Perencevich EN, Diekema DJ, Herwaldt LA, Smith TC, Chrischilles EA, et al. Comparative effectiveness of beta-lactams versus vancomycin for treatment of methicillin-susceptible Staphylococcus aureus bloodstream infections among 122 hospitals. Clin Infect Dis. 2015 Aug 1;61(3):361–7.
4. Goto M, Jones MP, Schweizer ML, Livorsi DJ, Perencevich EN, Richardson K, et al. Association of Infectious Diseases Consultation With Long-term Postdischarge Outcomes Among Patients With Staphylococcus aureus Bacteremia. JAMA Netw Open. 2020 Feb 5;3(2):e1921048.

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