It took a lot of time to make this video, because there are controversial theories on the mechanism of action of aminoglycosides.
Mainly, aminogycosides are thought to inhibit
1. Translation/ initiation
2. Translation/elongation(misreading, block translocation)
Some questions match only translation/initiation.
Recently, however, some researchers describe " Aminoglycosides don't inhibit the association of 50S and 30S." Probably this won't impact your exams, please check the textbook and recent questions.
#pharmacologymadeeasy #biochemistrynotes #biochemistrystudent
(Pictures) I express my gratitude and respect for your wonderful achievements.
1.Jeff Dahl
“Diagram of gram –negative cell wall”
File:Gram negative cell wall-cs.svg
2.Graevemoore
“Illustrates differences between Gram-positive and gram-negative bacteria”
File:Grampositiivse ja gramnegatiivse bakteri rakuseina erinevused ja sarnased.png
3.Kevin M. Krause, Alisa W. Serio, Timothy R. Kane, Lynn E. Connolly
“Aminoglycosides: An Overview”
Cold Spring Harb Perspect Med. 2016 Jun; 6(6): a027029.
doi: 10.1101/cshperspect.a027029
4.Picture of the kidneys.
WebMD
[ Ссылка ]
5. streptmyces
streptmyces genome project server.
streptmyces.nih.go.jp
6. Chest X-ray of a person with advanced tuberculosis:
Cited from Centers for Disease Control and Prevention’s Public health Image Library (PHIL), with identification number #2543
7. ear, brain
Pixabay. pixabay.com
(Reference) I express my gratitude and respect for your wonderful achievements.
1.Kevin M. Krause, Alisa W. Serio, Timothy R. Kane, Lynn E. Connolly
Aminoglycosides: An Overview.
Cold Spring Harb Perspect Med. 2016 Jun; 6(6): a027029.
doi: 10.1101/cshperspect.a027029
2.Albert Tsai, Sotaro Uemura, Magnus Johansson, Elisabetta Viani Puglisi, R. Andrew Marshall, Colin Echeverría Aitken, Jonas Korlach, Måns Ehrenberg, Joseph D. Puglisi.
The Impact of Aminoglycosides on the Dynamics of Translation Elongation. Cell.VOLUME 3, ISSUE 2, P497-508, FEBRUARY 21, 2013
DOI:[ Ссылка ]
3. Sylvie Garneau-Tsodikova and Kristin J. Labby
Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives. Medchemcomm. 2016 Jan 1; 7(1): 11–27.
Published online 2015 Sep 21. doi: 10.1039/C5MD00344J
4. MarkKesterPhD, Kelly D.KarpaPhD, Kent E.VranaPhD
Treatment of Infectious Diseases
Elsevier's Integrated Review Pharmacology (Second Edition) 2012, Pages 41-78
[ Ссылка ]
5. Françoisevan BambekeMarie-PauleMingeot-LeclercqYouriGlupczynskiPaul M.Tulkens
Mechanisms of Action
Infectious Diseases (Fourth Edition)
Volume 2, 2017, Pages 1162-1180.e1
6. Arun Mattaappalil, Kari A. Mergenhagen.
Neurotoxicity with Antimicrobials in the Elderly:A Review.
Clinical Thrapeutics?vol36, 2014 p1489-1511.
7. Sylvie Garneau-Tsodikova and Kristin J. Labby
Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives.
Medchemcomm. 2016 Jan 1; 7(1): 11–27
doi: 10.1039/C5MD00344J
(Musics) Youtube free music.
And once again, thanks for 200 subscribers. I'll try to make more and more helpful and reliable videos.
![](https://i.ytimg.com/vi/1qZA-pG_zMA/maxresdefault.jpg)