Mar Tintoré, MD, PhD, Vall d'Hebron University Hospital, Barcelona, Spain, talks on progression independent of relapse activity in multiple sclerosis (MS). The current classification categorizes MS as progressive when it has a score of 4 on the Expanded Disability Status Scale (EDSS) and is based on visible relapse-associated progression. However, it has been shown that a much higher proportion of the disability in MS is accumulated due to silent progression, which is independent of relapse activity. This silent progression is especially important in the early stages of the disease. This interview took place during the XXV World Congress of Neurology.

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