The cofactor is a specific molecule that is non-pretentious. It is not built of proteins but some enzymes need this cofactor to run the biochemical reaction.
The cofactors get combined with the enzyme and activate it. this way, it forms the non-proteinous part of the enzyme.
Cofactor molecule could be organic or inorganic. For further details, WATCH THE VIDEO...
Cofactors and Coenzymes (Holo-enzyme, Apo-enzyme and MORE)
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