In this video I have explained about bile acid synthesis
Video includes steps of synthesis, key enzyme ( 7 alpha hydroxylase), primary bile acids( cholic acid and cheno deoxycholic acid),conjugation with glycine and taurine ,secondary bile acids ( deoxycholic acid and lithocholic acid),role of nuclear bile acid binding receptor called as Farnesoid X receptor and FXR agonist like obeticholic acid role in primary biliary cholangitis/primary biliary cirrhosis
NEET PG MCQ also added
#bileacidsynthesis
#farnesoidxreceptor
00:00 Introduction to bile acid synthesis
00:23 Important products from cholesterol
01:26 Rate limiting step of bile acid synthesis
01:34 bile salts vs bile acids vs bile pigments
02:20 Primary bile acids
02:40 Conjugation of primary bile acids
03:33 Deconjugation to secondary bile acids
04:05 Bile salts formation
04:40 Regulation of bile acid synthesis
05:35 Role of FXR agonist in biliary cholangitis
06:40 MCQ 1 NEET PG Bile acid synthesis
07:08 MCQ 2 NEET PG Bile acid synthesis
08:11 MCQ 3 NEET PG Bile acid synthesis

bile acids are synthesized from cholesterol
KEY enzyme of bile acid synthesis is 7 Alpha hydroxylase which is a microsomal enzyme
primary bile acids are cholic acid and chenodeoxycholic acid
primary bile acids are conjugated with the help of glycine and taurine
Conjugated primary bile acids are deconjugated in intestine by intestinal bacteria.
Cholic acid is the deconjugated to deoxycholic acid while chenodeoxycholic acid is deconjugated to lithocholic acid
At alkaline pH of bile this bile acids exist as Sodium and potassium salts called as a bile salts.
bile salts play important role in in digestion of lipids

nuclear receptor that is bile acid binding receptor called as Farnesoid X receptor play a important role in suppresson of transcription of of gene of 7 Alpha hydroxylase.
when bile acid pool increase chenodexoxycholic acid bind with the farnesoid X receptor
and suppress 7 alpha hydroxylase and and so bile acid synthesis reduced.
FXR agonist like obeticholic acid is used in primary biliary cholangitis

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