When does the neonatal brain lack Oxygen or Blood? Why does this cause HIE? What is its pathophysiology? How do we diagnose it? What are the important physical exam findings and blood work we would expect? This is part I of two videos on Hypoxic Ischemic Encephalopathy. (Part II will be on treatment or hypothermic therapy).
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What causes HIE? What are the stages? How do we perform a neurological exam for HIE patients? Learn all about the pathophysiology and diagnosis in part I of this series.
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Dr. Tala is a board-certified neonatologist, and has worked in busy level III and IV units for the past 15 years. She has won multiple teaching awards throughout her time as a neonatologist.
Timecodes
0:00- Introduction
1:25- The pathophysiology of HIE
2:12- The Diving Seal Reflex
3:00- HIE and cell injury
4:22- The reperfusion injury stage
5:25- The diagnosis of HIE
6:12- Risk factors for HIE
7:06- What is considered significant resuscitation
7:42- Pertinent lab values
9:08- The blood gas: pH and base deficit
11:15- The physical exam
11:57- The neuro exam
13:53- The stages of HIE
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Power, B., McGinley, J., and Murphy, J. (2019). The modified sarnat score in the assessment of neonatal encephalopathy: A Quality improvement initiative. The Irish Medical Journal. Retrieved from [ Ссылка ]
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Apgar scoring for newborn health assessment. (2021). American Baby and Child Law Centers. Retrieved from [ Ссылка ]
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Worden, L.T. and Massey, S.L. (2020). Therapeutic hypothermia effects on brain development. Practical Neurology. Retrieved from [ Ссылка ]
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Bhat, B.V. and Adhisivam, B. (2014). Therapeutic cooling for perinatal asphyxia-indian experience. Indian Journal of Pediatrics, 81 (6), 285-591. doi: 10.1007/s12098-014-1348-0
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Why babies with HIE may have multi-organ failure. (2017). American and Baby Child Law Centers. Retrieved from [ Ссылка ]
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Apoptosis. (2021). National Human Genome Research Institute. Retrieved from [ Ссылка ]
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Deorari. (2008). Blood gas analysis. Newborn WHOCC. Retrieved from [ Ссылка ]
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Coping with hypotonia. Speech Buddies. Retrieved from [ Ссылка ]
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Griff, A.M. (2018). Causes and treatment for dilated pupils. Medical News Today. Retrieved by [ Ссылка ]
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*Disclaimer*: This video is intended for educational purposes only and while
we strive to give the most accurate information, errors may occur. Subsequently,
this video should not be a replacement for medical advice.
