Explore the difference between difference SSRIs such as Fluoxetine, Fluvoxamine, and Paroxetine.
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The video discusses the differences between various SSRIs, focusing on fluoxetine (Prozac), fluvoxamine (Luvox), and paroxetine (Paxil). Fluoxetine is noted for its effects on 5ht2c receptors and its approval for depression, OCD, panic disorder, bulimia, and PMDD. It has the lowest risk for weight gain, a long half-life, and is commonly used in children over eight. Fluvoxamine primarily targets sigma receptors and is FDA-approved for OCD but not depression due to its high risk for drug interactions. Paroxetine affects M1, NET, and nitrous oxide synthetase receptors, approved for a variety of conditions including MDD, OCD, and panic disorder. However, it's known for antimuscarinic effects, weight gain, severe discontinuation syndrome, and potential birth defects. Each SSRI has unique properties and indications. Zoloft is noted for atypical depression and minimal interactions. Lexapro is described as the purest SSRI with fewer side effects but a mild QTc increase. Celexa has some QTc concerns due to its enantiomer. Overall, the video offers concise summaries of each SSRI's characteristics, indications, and potential side effects to aid in clinical decision-making.
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