Use Nova to skip the first phase by destroying all the vents with her 2 and a Tigris. Builds are unimportant, just use Vitality, and Adaptation if you have it. Build for duration to maximise the damage reduction from your 1. My secondary is a tombfinger, but any good weapon will do the trick.

The second phase is mostly on rails and limited by the timer, just throw some thermia now and then and make sure to shoot the cannisters. The small spiders don't really matter beyond dropping cannisters.

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