The sequencing of the human genome provided a template with encrypted sequences within that are the code for life. The genome sequence has allowed us to map which regions of our genome associated with human disease. Surprisingly, the efforts to map human genetic diversity have pointed to many regions of DNA previously considered "junk DNA" as critical for human health. Junk DNA comprises approximately 95% of our genome that doesn't encode for protein genes that have been the predominant focus of modern medicine. Yet more recently profound new clues to human health and disease have arisen from the junk DNA.
Here we will discuss the biological treasures that have been identified in the noncoding genome in a historical context.
John L. Rinn is an assistant professor of Stem Cell and Regenerative Biology at Harvard University and Medical School and Senior Associate Member of the Broad Institute.
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