A recent paper in Development (Volume 143 Issue 23) from James Nichols, Charles Kimmel and colleagues shows that phenotypic variability in mef2ca mutants is due to variable fate switching from ligament to bone.
Movie 3 from the paper show the differentiation of bone in place of ligament. Movie 4 shows that the bone cells derive from the same progenitor cells that usually form ligaments.
Find out more from the paper:
[ Ссылка ]
And you can read an interview with first author James Nichols on the Node:
[ Ссылка ]
