Link to free download of my 2 textbooks
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Physiology book in hard copy
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Pathophysiology book in hard copy
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US variants data
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US omicron history
November 29
Index patient, 48 year old unvaccinated man, Nigeria
Nebraska, 6 people diagnosed by PCR and genomic sequencing
Onset was 73 hours (range = 33–75 hours)
Incubation period
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Original version, five days
The Delta variant, four days
Omicron, 2 to 3 days
Viral Load
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Alpha and Delta variants
Peak viral load 3 days after infection
Clear the virus about six days after that
Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron
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Omicron and Delta produced similar levels of infectious virus
Infections a day shorter with omicron compared to delta
Omicron infects upper airways as opposed to lungs
Omicron antibodies neutralise delta virus
Offshoot of Omicron variant, England
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BA.2 may be even more contagious than original omicron
UK Health Security Agency
Designating BA.2 a variant under investigation
increasing numbers of BA.2 sequences identified both domestically and internationally
May have an increased growth rate over BA.1
Vaccine effectiveness with omicron
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After a 2-dose primary course of vaccination
Vaccine protection against mild disease has largely disappeared by 20 weeks after vaccination
After a booster dose
Protection initially increases to around 65 to 70%
but drops to 45 to 50% from 10+ weeks
Therefore
It is therefore likely that current vaccines offer limited long-term protection against infection or transmission.
Protection against severe disease
Vaccine effectiveness against hospitalisation is estimated at 92%
and remains high at 83% 10+ weeks after the booster dose
John’s booster
20th November
So my protection against hospitalisation goes down from 92% to 83% by soon
