Upon meeting the family of the patient, House begins a bet to determine whether they are his biological parents. Somehow the word spreads to the rest of the hospital eventually reaching Cudddy and surprisingly she wants in.

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Season 1 Episode 2 "Paternity"
A 16-year-old high school student, Dan (Scott Mechlowicz), starts suffering night terrors and frequent hallucinations after playing lacrosse at school. Dan's parents take him to see Dr. House after receiving a letter that Cameron sent in House's name. After Dan exhibits more symptoms, including a myoclonic twitch and a blocked blood vessel, House diagnoses Dan. Dan suffers from an auditory hallucination during a procedure, however, ruling out House's diagnosis. Using coffee cups from the parents, House does an unauthorized paternity test and discovers that neither parent is biologically related to Dan. House flashbacks to a case he had earlier that involved a mother who did not want her baby to be vaccinated and theorizes that Dan is suffering from a measles virus contracted during his childhood. House confirms his diagnosis with a retinal biopsy and successfully cures Dan.

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