How to Increase Growth Hormone with MK-677 (Ibutamoren): Benefits, Dosing, Side Effects.
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MK-677 (Ibutamoren): Benefits, Dosing, Side Effects.
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_____________________Topics Discussed_____________________
@0:00 Intro
* MK-677 agonist of the GHS-R1a (same as GHRP2, GHRP6, and Ipamorelin)
* Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor.
* Ghrelin mimetic (hunger hormone)
* Stimulates the secretion of growth hormone by the pituitary gland
* Growth Hormone vs Insulin
* growth hormone secretion, significantly increased fat-free mass
* Increase IGF-1 to optimal levels (often 50% increase, not supra physiological)
* increases insulin sensitivity
* doesn’t help to decrease adipose tissue as much as other GHA
* Orally bio-available
* half-life 4-6 hours
@3:00Used for
* Sub-optimal Growth Hormone/IGF-1 (Increases chances of mortality)
* Heart Health
* Memory and Learning
* Increasing Muscle Mass
* Recovery and Repair form Injuries
* Stimulating Appetite (sarcopenia)
* Better Sleep Quality
* Regeneration of Nerves
@4:15 Side Effects
* First week increase in Cortisol and Prolactin (probably not clinically significant)
* balances out after 14 days
* Insulin resistance first 6 weeks goes away at 24 weeks ( often weight loss by this time)
@5:05 Dose/Administration
* 25mg capsules on an empty stomach, away from sugar ( Growth Hormone vs Insulin)
* Evening to stimulate GH secretion
* Morning if you are going to fast
@6:15 Contraindications
* Cancer
* Pregnant or Breastfeeding
* Thyroid?
* Corticosteroids?
* Diabetes
* Allergy
Go get your levels checked!
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-------------------------------------Studies-------------------------------------
PMID:8954023
PMID:9329386
PMID:9467534
Chapman, I. M., Pescovitz, O. H., Murphy, G., Treep, T., Cerchio, K. A., Krupa, D., … Thorner, M. O. (1997). Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults*. The Journal of Clinical Endocrinology & Metabolism, 82(10), 3455–3463. [ Ссылка ]
Catabolism, R. D., Murphy, M. G., Plunkett, L. M., Gertz, B. J., He, W., Wittreich, J., … Clemmons, D. R. (1998). MK-677 , an Orally Active Growth Hormone, 83(2), 320–325.
Sigalos, J. T., & Pastuszak, A. W. (2018). The Safety and Ef fi cacy of Growth Hormone Secretagogues, 45–53. [ Ссылка ]
DISCLAIMER: The information provided in this video is for entertainment purposes only and IS NOT MEDICAL ADVICE. If you have questions about your health contact a medical professional.This content is strictly the opinion of Dr. Michael Moeller and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Michael Moeller nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
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