Nerve agents are completely terrifying - in this episode I discuss the different classes of nerve agents, and we determine which ones are the most EVIL.
Exposure to nerve agents is usually treated with atropine and pralidoxime chloride (2-PAM chloride).
Nerve agents inhibit acetylcholinesterase, which is an enzyme that catalyzes the breakdown of acetylcholine. Some nerve agents covalently bind to the enzyme, and can damage the active site of the enzyme, so the acetylcholine builds up, the signal keeps sending, and the motor neurons keep firing. The G series and V series of nerve agents were mass produced, weaponized agents, while the EA series, A series, and others are not known to be mass produced or weaponized.
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Second Discord link if the first one is borked - [ Ссылка ]
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References:
(Graphic) Rabbits exposed to nerve agents - [ Ссылка ]
Scary book - Jared Ledgard, A Laboratory History of Chemical Warfare Agents - (the link to this book was deactivated; perhaps the uploader had violated the hosting site's TOS - its ISBN-13 number is 978-0615136455)
Methyl cyclosarin treatment patent - [ Ссылка ]
Earliest Methyl cyclosarin reference - [ Ссылка ]
Previous Tierlist - [ Ссылка ]
Hydrolysis of VX/EA-2192 - [ Ссылка ]
VR 'first Novichok' - [ Ссылка ]
SL-599 (SB-8) paper - [ Ссылка ]
Perfect 10 patent - [ Ссылка ]
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Molecules for this tierlist - Tabun (GA), Sarin (GB), Chlorosarin, Thiosarin (GBS), Soman (GD), Cyclosarin (GF), Methyl cyclosarin (EA-1356), VX, EA-2192, Russian VX (VR), Chinese VX, V-sub x, A-230, A-234, A-242, C01-A039, C01-A042, Neostigmine, TMTFA, TL-599 (SB-8), T-1123, T-1152, 4-692-530-01, 4-686-293-01 (Agent 1-10), 4-686-293-02 (Agent 1-8)
Tierlist Playlist - [ Ссылка ]
