In 1947, Marie was able to successfully complete her thesis titled “A Study of the Products Formed By the Action of Pancreatic Amylase on Corn Starch”, and earned her PhD. in chemistry; Marie Daly became the first African-America woman to earn a PhD. in chemistry. From 1947 to 1948 Marie worked as a physical science instructor at Howard University while conducting research with Herman Branson on the side.
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