Professor Brian Kennedy from the National University of Singapore is one of the world's leading researchers in the longevity field and has done longevity research for more than two decades. He is active in many different longevity companies and has been the President and CEO at Buck Institute for Research on Aging. Throughout the years he has made many different important and revolutionary longevity discoveries. Currently he is also one of the persons who is trying to move the longevity forward in a much efficient and faster way. This work he is doing in Singapore where he is leading a huge longevity research project. This unique project is something we are going to talk about in the podcast. We will also talk about his research on Rapamycin and other interesting longevity topics.
00:00 Intro
02:13 Longevity interest and research
04:07 Lifespan discovery of sir2 in yeast
06:42 Lifespan discovery of TOR (mTOR) in yeast
07:14 mTOR and calorie restriction
09:19 mTOR and mechanistic downstream effects
09:55 mTOR activation and inhibition
10:20 Problem with mTOR chronic overactivation
12:41 Challenges in Singapore and in the world
13:19 Increase healthspan by slowing aging
14:37 Create a pipeline for healthy longevity
16:54 Potential in squaring the longevity curve
18:48 Validation of longevity interventions
21:00 Different biological clock
23:52 Connect the longevity pieces together
25:00 Hallmarks of aging
26:11 Seven pillars of aging are connected
27:58 Aging the biggest risk factor for age-related diseases
30:51 Combining longevity interventions
33:14 Risk of too much mTOR inhibition
36:14 Alpha-ketoglutarate (AKG)
39:38 Who benefits best in taking AKG
40:55 Brian's longevity stack
42:12 His experiences with Rapamycin
45:58 Cycling mTOR inhibition
48:20 Things to keep an eye on when taking Rapamycin
49:24 Start of a Rapamycin longevity trial
51:49 Rapalogs - Next generation mTOR inhibitors
53:02 Other ways to inhibit mTOR
54:44 Low vs high protein intake for longevity
57:26 Personalized longevity interventions
1:00:35 Personalized mTOR inhibition
1:01:43 Most promising longevity interventions
1:03:27 Brian's longevity protocol
1:06:28 How can longevity community speed up things
1:08:37 Contact information
Links
- The centre for Healthy Longevity at the National University of Singapore
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- Healthy Longevity webinars on Youtube
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- Brian's LinkedIn
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- Brian's Twitter account
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Rapamycin resources
- Rapamycin Longevity Lab
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- Rapamycin.news
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- Rapamycin Facebook group
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- Rapamycin Reddit group
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Connect with Krister on:
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Disclaimer: The podcast is for general information and educational purposes only and is not medical advice for you or others. The use of information and materials linked to the podcast is at the users own risk. Always consult your physician with anything you do regarding your health or medical condition.
