In this clip David Sinclair talks about the reason that you should keep your NMN cold; in the fridge or in the freezer.
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NMN or Nicotinamide Mononucleotide is the pre-cursor to NAD+ (Nicotinamide Adenine Dinucleotide), NAD is found in nearly all our living cells. NAD is essential for sustaining life, David Sinclair (a professor at Harvard Medical School) once said if we suddenly didn’t have NAD we would be dead within eight seconds.’ Unfortunately, as we age our NAD levels drastically decline, clinical studies have shown that by age of 50 a typical person could have half the NAD+ they did in their youth and by the age of 80 our NAD+ (Nicotinamide Adenine Dinucleotide) levels drop to around 1% to 10% of those enjoyed in our youth. NAD is biologically unstable, which makes it unsuitable for oral supplementation. Fortunately, it is easy to restore our cellular NAD levels using NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside), which convert to NAD when it is in the cell. These NAD boosting supplements can be purchased from reputable companies such as Do Not Age, Alive by Science and Pro-health Longevity. A fascinating aspect of NAD+ is its dual role in protecting against factors that age us. This includes mitigating chemical stress, inflammation, DNA damage and failing mitochondria; all conditions associated with aging. In other words, while a decline in NAD+ levels may negatively influence lifespan and Healthspan (health-span), so restoring NAD+ is increasingly being viewed as a scientific way to promote longevity and a way to combat the diseases of aging too. A rigorous scientific review of NAD+ reveals that its longevity benefits arise from eight different, but interrelated, functions. In 2013 a scientific study; 2-year old mice were tested for muscle wastage, insulin resistance and inflammation, all are, on humans used as indicators of the aging process, they were then given NMN (Nicotinamide Mononucleotide) for 1 week. In all cases, after only 1 week the 2-year old mice were reflecting the expected findings of 6-month old mice in the areas of muscle wastage, insulin resistance and inflammation. In human terms that would be comparable to a 75-year old having the results you would expect from a 25-year old. In a later methodical study, in 2018, again on mice, Dr. David Sinclair’s team at the Harvard Medical School found that the aging of blood vessels had been reversed. The science showed that mice that were given NMN (Nicotinamide Mononucleotide) had restored blood vessel growth and had increased muscle endurance by up to 80%. Supplementation with NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) has been shown to slow cellular aging in mice and improve many metabolic defects common to degenerative processes, including muscle wastage, insulin resistance and inflammation. Nicotinamide mononucleotide ("NMN", "NAMN", and "β-NMN") is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH). In mice, NMN enters cells via the small intestines within 10 minutes converting to NAD+ through the Slc12a8 NMN transporter. Because NADH is a cofactor for processes inside mitochondria, for sirtuins, and for PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent. Doses of up to 500 mg was shown safe in men in a recent scientific human study at the Keio University School of Medicine, Japan. Multiple long-term scientific human studies are underway. Supplementing with NMN may prevent the diseases of aging. An aging-associated disease is a disease that is most often seen with increasing frequency with increasing senescence

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