In a recent publication in the prestigious journal Nature, Vera Gorbunova and her research team have made a remarkable discovery. They have successfully extended the lifespan of mice by genetically modifying them to produce an enzyme called HMM-HA. This genetic alteration not only increased the mice's longevity but also significantly reduced their risk of developing cancer.
Furthermore, their study introduces a fascinating gene called nmrHAS2, derived from naked mole rats. When introduced into mice, this gene led to impressive improvements in the lifespan and healthspan of these rodents:
- Mice with the nmrHAS2 gene experienced a remarkable 4.4% increase in median lifespan and an astonishing 12.2% increase in maximum lifespan.
- Older mice carrying the nmrHAS2 gene demonstrated a substantial 34% reduction in cancer incidence when compared to their counterparts without the gene.
- These genetically enhanced mice also exhibited fewer signs of age-related physical dysfunction, as measured by frailty index scores. This assessment considered the deterioration of various tissues and organs in aging.
This groundbreaking research provides compelling evidence that genes from long-lived species, such as naked mole rats, can be transferred to other species, potentially offering significant benefits. The implications of this discovery hold promise for the potential enhancement of human longevity and health in the future.
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