Adrenal Fatigue Fix (Causes, Symptoms, Treatment)

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Adrenal glands produce hormones necessary for normal body functioning; the deficiency of these hormones is called adrenal insufficiency. Adrenal insufficiency can present along a spectrum ranging from mild nonspecific symptoms to life-threatening shock. The decrease in adrenal function may be masked until stress or illness triggers an adrenal crisis. This activity reviews the evaluation and management of adrenal insufficiency and highlights the role of interprofessional team collaboration in the recognition and management of adrenal insufficiency.

The adrenal gland is made up of two parts, the cortex and the medulla. The adrenal cortex produces hormones necessary for normal body functioning; deficiency of these hormones results in adrenal insufficiency. The cortex is responsible for producing glucocorticoids, mineralocorticoids, and androgens. Destruction or dysfunction of the adrenal cortex mainly causes glucocorticoid and mineralocorticoid deficiency. Primary adrenal insufficiency is also known as autoimmune adrenalitis or Addison disease.

Adrenal insufficiency ranges from mild nonspecific symptoms to life-threatening shock conditions. Due to its vague symptoms and varying degree of clinical presentation, a clinician must maintain a high level of suspicion for this disease. The decreasing or suppressed adrenal function may be masked until stress or illness triggers an adrenal crisis.

Adrenal insufficiency can be classified into primary, secondary, and tertiary causes. Primary adrenal insufficiency occurs when there is a pathology affecting the adrenal gland itself. Secondary adrenal insufficiency results from a decreased level of adrenocorticotrophin hormone (ACTH) released from the pituitary gland, and tertiary adrenal insufficiency results from a decreased level of corticotrophin-releasing hormone (CRH) released from the hypothalamus.

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