Ketamine works to treat chronic pain by blocking an important receptor in the brain called NMDA.

NMDA is a receptor that perpetuates chronic pain over and above what we're used to experiencing.

For example, imagine that you tripped, and fell, and broke your leg or you broke your hip. It's a very painful experience. We've all had very painful experiences in our lives before, but eventually, the pain goes away. Right?

Maybe after a few weeks of a few months.

With chronic painful circumstances, such as herniated disks that cause pain in the back and pain radiating down the leg, that pain never goes away.

The reason it doesn't go away is because once the spinal cord continues to be barraged over and over again by these painful impulses, it activates the NMDA receptor in the brain, and NMDA essentially strips the inherent breaks in the central nervous system that prevent the pain from getting out of control. So, when people have pain for more than six months to a year, it can activate NMDA. NMDA gets shut down by ketamine.

That's one of the really fortuitous uses that we found for ketamine. It essentially blocks NMDA, and it blocks that over the perpetuation of painful impulses in the brain.

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