An overview of the SARS-CoV-2 (aka Coronavirus aka COVID) virus, the Spike protein, and the mRNA vaccine BNT162b2 developed by Pfizer and BioNTech.




Other places you can find content from me:

Blog - The Cynical Philosopher
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Twitter - @AuthorTomHarper
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Amazon - Author Profile
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My science fiction series available on Amazon
Incarnate: Existence
Incarnate: Essence
Incarnate: Schism


Resources and References

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates
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Guidelines on clinical evaluation of vaccines: regulatory expectations
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Decoding the SARS-CoV-2 Genomes – Origin
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Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak
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Genomic variance of the 2019-nCoV coronavirus
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The Human Coronavirus Disease COVID-19: Its Origin, Characteristics, and Insights into Potential Drugs and Its Mechanisms
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Humanized mice develop coronavirus respiratory disease
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Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS-CoV-2
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Crystal structure of SARS-CoV-2 papain-like protease
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Distinct conformational states of SARS-CoV-2 spike protein
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Broad-Spectrum Coronavirus Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus Diseases
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Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
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Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
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Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?
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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
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TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
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mRNA vaccines — a new era in vaccinology
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The promise of mRNA vaccines: a biotech and industrial perspective
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Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections
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Peripheral Blood Mononuclear Cells: A Brief Review
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PDB Codes:
6VXX – SARS-CoV-2 Spike Protein (pre-fusion conformation)
6VYB – SARS-CoV-2 Spike Protein (pre-fusion conformation)
6VW1 – SARS-CoV-2 Spike Protein (pre-fusion conformation)
6ACK – SARS-CoV Spike Protein + Human ACE2
6XRA – SARS-CoV-2 Spike Protein (post-fusion conformation)

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