This video is sponsored by Brilliant. The first 200 people to sign up via [ Ссылка ] get 20% off a yearly subscription. To make antivenom, you first need to collect venom from the world’s most deadly snakes.
Huge thanks to the Australian Reptile Park for having us over to film – special thanks to Zac Bower for milking all of these snakes for us and Caitlin Vine for organizing the shoot. Absolute legends. [ Ссылка ]
Huge thanks to Dr Timothy Jackson from the Australian Venom Research Unit for answering our questions, and fact checking the script. This video would not have been the same without you.
Thanks to Seqirus Australia for providing B-roll footage of the horses and the antivenom production.
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References:
Calmette, A. (1896). Le venin des serpents: Physiologie de l'envenimation, traitement des morsures venimeuses par le sérum des animaux vaccinés. Paris: Société d'éditions scientifiques.
Broad, A. J., Sutherland, S. K., & Coulter, A. R. (1979). The lethality in mice of dangerous Australian and other snake venom. Toxicon, 17(6), 661-664. – [ Ссылка ]
WHO Expert Committee on Biological Standardization. (2016). WHO guidelines for the production, control and regulation of snake antivenom immunoglobulins. Geneve, Switzerland. – [ Ссылка ]
Calmette, A. (1896). The treatment of animals poisoned with snake venom by the injection of antivenomous serum. British medical journal, 2(1859), 399. – [ Ссылка ]
Hawgood, B. J. (1999). Doctor Albert Calmette 1863–1933: founder of antivenomous serotherapy and of antituberculous BCG vaccination. Toxicon, 37(9), 1241-1258. – [ Ссылка ]
Pucca, M. B., Cerni, F. A., Janke, R., Bermúdez-Méndez, E., Ledsgaard, L., Barbosa, J. E., & Laustsen, A. H. (2019). History of envenoming therapy and current perspectives. Frontiers in immunology, 1598. – [ Ссылка ]
Kang, T. S., Georgieva, D., Genov, N., Murakami, M. T., Sinha, M., Kumar, R. P., ... & Kini, R. M. (2011). Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis. The FEBS journal, 278(23), 4544-4576. – [ Ссылка ]
Hawgood, B. J. (2007). Albert Calmette (1863–1933) and Camille Guerin (1872–1961): the C and G of BCG vaccine. Journal of medical biography, 15(3), 139-146. – [ Ссылка ]
Vonk, F. J., Admiraal, J. F., Jackson, K., Reshef, R., de Bakker, M. A., Vanderschoot, K., ... & Richardson, M. K. (2008). Evolutionary origin and development of snake fangs. Nature, 454(7204), 630-633. – [ Ссылка ]
Bochner, R. (2016). Paths to the discovery of antivenom serotherapy in France. Journal of Venomous Animals and Toxins including Tropical Diseases, 22. – [ Ссылка ]
Young, B. A., Herzog, F., Friedel, P., Rammensee, S., Bausch, A., & van Hemmen, J. L. (2011). Tears of venom: hydrodynamics of reptilian envenomation. Physical review letters, 106(19), 198103. – [ Ссылка ]
Madras Medical Journal, Volume Second, July-December 1870. Page 355
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Written by Petr Lebedev and Derek Muller
Edited by Trenton Oliver
Filmed by Jason Tran and Petr Lebedev
Animation by Fabio Albertelli, Jakub Misiek, Ivy Tello and Mike Radjabov.
Molecule animation by Reciprocal Space – [ Ссылка ]
Additional video/photos supplied by Getty Image
B-roll supplied by Seqirus Australia
Music from Epidemic Sound and Jonny Hyman
Thumbnail by Ignat Berbeci
Produced by Derek Muller, Petr Lebedev, and Emily Zhang
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