Gonadorelin for TRT and its clinical use for patients on testosterone replacement therapy.
Does Gonadorelin work as well as hCG?
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At NovaGenix Testosterone Replacement Therapy we’ve had many patients asking the same question "Why did my doctor switch me from hCG to Gonadorelin?" The answer most likely is due to recent FDA regulatory changes in compounding pharmacies and their ability to manufacture hCG, which is short for human chorionic gonadotropin. On March 23rd 2020, new rules went into place regarding the manufacturing of certain medications that are considered to be "biologics." hCG is among the medications concerned.
As a result, most pharmacies had to stop making and dispensing compounded hCG. This in turn caused a supply shortage, while increasing demand and ultimately the costs.
Get prescribed HCG with your HRT protocol There are many clinics and physicians whom may be misinformed about the changes in FDA regulations and are telling patients that hCG is now "illegal" or no "longer available". Fortunately, this is not the case, and there is still medicine available for the many men on TRT who have come to rely on it as part of their HRT protocol. Many pharmacies are still getting brand name hCG like Pregnyl from Merck, for example but often the cost of brand name hCG is substantially more than from a compounding pharmacy.
Many clinics are switching to Gonadorelin as a replacement for hCG and this has raised the question, "Does Gonadorelin work?" Interestingly, the answer actually depends on your dose and protocol.
Studies have shown it to be effective in maintaining testicular functioning and size for both fertility and HRT treatments, however there's a catch. The issue with using Gonadorelin is that is has an extremely short half-life. The half-life of a medication is the time that it takes half of the dose to be metabolized and eliminated from the blood stream. For Gonadorelin, the half-life is between 2 and 10 minutes depending on how quickly a person metabolizes the medication and a terminal half-life of 10-40 minutes. (That's how long it takes for it to be out of your system completely). For this reason, the administration route used during clinical applications which has been studied and published was a portable infusion pump which can provide a pulsatile subcutaneous administration of the gonadorelin, which was necessary to achieve positive results for use on male subjects in an attempt to increase sperm production, testosterone production and maintain testicular functioning. So for these subjects, a needle was implanted inside the abdominal wall and medication was then administered by a pump every 90 minutes.
The issue is that hCG has a half life of approximately 36 hours compared to gonadorelin's 2 to 20 minutes. In order to perform the same job as hCG, you would need a constant supply of gonadorelin pulsated into your bloodstream every 60-90 minutes and this makes it a very inconvenient medication for most TRT patients who would not want to give themselves 6-10 injections daily or be fitted with an infusion pump.
A similar clinical trial sponsored by Massachusetts General Hospital used a micro-infusion pump which injected every 2 hours. while despite being around and available since 1978 under the brand name Factel, Gonadorelin has never been used as an LH analogue over human chorionic gonadotropin for testosterone therapy until the recent regulatory changes made it more difficult to fill hCG prescriptions.
Can I Still Get hCG?
Yes, Absolutely. There are many options available from reputable licensed US pharmacies. There are many online pharmacy websites which market and sell medications, however they are illegal and lack the oversite and testing that US based accredited pharmacies undergo for purity and sterility of all medications they manufacture and distribute. If you would like more information on how to get started with TRT and hCG, we'd be happy to schedule an initial online consultation with our physician who can help you get tested, diagnosed and treated for Low T. Our all inclusive programs include all medications, including testosterone, and hCG. We provide convenient, affordable and effective treatments with a medical team who specializes in Low-T therapy for men. Call or Text NovaGenix at 561-277-8260 or visit us online to learn more about our online Testosterone Replacement Therapy programs. If you would like to set up a consultation, you can fill out our online new patient intake form and email us any blood work you may have to info@novagenix.org
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