An intravital four-dimensional data set showing wild-type mouse neutrophils (red) swarming around a central point of localized tissue damage and the failure of talin-deficient (integrin-defective) neutrophils (green) to participate in swarm formation in a mouse ear. Both types of neutrophils migrate equivalently in the dermis, showing that high affinity integrin function is not necessary for such movement in dense tissue but is required for isolating the damage from surrounding viable tissue.

See Lämmermann T, Afonso PV, Angermann BR, Wang JM, Kastenmüller WK, Parent CA, Germain RN. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature. 2013 Jun 20;498(7454):371-375.

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