All you need to know about the COP I and COP II Vesicle Formation!
Video Links:
PART 1: ER TO GOLGI Transport: [ Ссылка ]
PART 2: KDEL and KKXX Sequence: [ Ссылка ]
Description:
COP II coated vesicles transport the protein from ER to Cis-Golgi (anterograde transport) whereas COP I coated vesicles transport ER resident protein back to ER from Cis-Golgi (Reterograde transport).
COP I vesicle formation: When KDEL receptor forms a complex with a protein, having KDEL sequence at C terminal, then that complex recruits SEC7 (a GEF, changes GDP to GTP). SEC7 changes ARF1-GDP (Inactive) to ARF1-GTP (active form). ARF is an adaptor protein which embeds its hydrophobic tail into the Golgi membrane after activation.
After that ARF-GTP recruits the subunit of COP I protein, due to which COP I coated vesicle gets formed.
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