In development, hematopoietic stem cells (HSCs) pass through a temporal niche capable of regulating stem cell numbers through a variety of molecular and cellular mechanisms. Using multi-omic analyses, multifluorescence tagging and live imaging, we identify, at Harvard Medical School, a population of primitive macrophages that recognize newly formed hematopoietic stem and progenitor cells (HSPCs) and regulate stem cell clonality into adulthood. These macrophages detect surface-bound calr isoforms present on HSPCs and engulf the entire cell or remove small fragments of cellular material and promote expansion.
CONTENT
00:00 36 Hour Zebrafish Embryo
00:25 Hematopoietic Stem Cell
01:00 Landing and Attachment on Caudal Hematopoietic Tissue
01:13 Extravasation
01:28 Migration to Abluminal Side
01:37 'Doomed' Stem Cell
01:54 'Groomed' Stem Cell
02:09 Endothelial Cuddling
02:32 72 Hour Zebrafish Embryo
02:46 96 Hour Zebrafish Embryo
SOURCE
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