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Chasing the Pump- Positive Effects on Muscle & What to do Next!

Study - American Journal of Physiology:

6 normal untrained men were studied during intravenous infusion of a balanced amino acid mixture (approximately 0.15 g.kg-1.h-1 for 3 h) at rest and after a leg resistance exercise routine to test the influence of exercise on the regulation of muscle protein kinetics by hyperaminoacidemia

The intravenous amino acid infusion resulted in comparable increases in arterial amino acid concentrations at rest and after exercise, whereas leg blood flow was 64% greater after exercise than at rest

During hyperaminoacidemia, the increases in amino acid transport above basal were 30-100% greater after exercise than at rest

Increases in muscle protein synthesis were also greater after exercise than at rest (291 +/- 42% vs. 141 +/- 45%)

Concluded that the stimulatory effect of exogenous amino acids on muscle protein synthesis is enhanced by prior exercise, perhaps in part because of enhanced blood flow

Results imply that protein intake immediately after exercise may be more anabolic than when ingested at some later time.

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Researchers concluded that net protein synthesis during amino acid administration can be doubled by previous performance of heavy resistance exercise

Moreover, the data suggest a link between the stimulation of protein synthesis after exercise and an acceleration in amino acid transport

The greater rate of transport after exercise may be due to the increase in blood flow

What the researchers concluded is that physical activity (such as weight lifting) improves delivery of amino acids to your muscles, enhancing repair and growth

So it stands to reason that further increasing blood flow, as a result of getting a pump, you can increase that amino acid delivery even more, leading to bigger and better gains that you would had you not gotten a pump

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**Nitric oxide Mechanism**

Nitric oxide modulates respiration due to it being a reversible inhibitor of cytochrome c oxidase (the last enzyme in the respiratory electron transport chain of cells located in the membrane)

Cytochrome blocks the respiratory chain, but nitric oxide inhibits/reverses cytochrome c oxidase

If respiratory chain is blocked, then nutrients aren’t getting through, but since NO inhibits cytochrome c oxidase, oxygen and other nutrients are able to get through


References

1) Biolo G , et al. (n.d.). An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. - PubMed - NCBI. Retrieved from [ Ссылка ]

2) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. - PubMed - NCBI. (n.d.). Retrieved from [ Ссылка ]

3) Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incrementa... - PubMed - NCBI. (n.d.). Retrieved from [ Ссылка ]

4) Van Rosendal SP , et al. (n.d.). Guidelines for glycerol use in hyperhydration and rehydration associated with exercise. - PubMed - NCBI. Retrieved from [ Ссылка ]

5) Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incrementa... - PubMed - NCBI. (n.d.). Retrieved from [ Ссылка ]

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