Methotrexate: friend or foe? If you're battling autoimmune diseases like rheumatoid arthritis or lupus, this episode is a must-watch. We delve into methotrexate’s history, how it combats autoimmune diseases, and what to expect when taking this medication.

💡Video Key Takeaways
✔️ Methotrexate has a long history of use in treating various rheumatic autoimmune diseases since its development in the 1950s.
✔️ Its mechanism of action remains somewhat uncertain, initially believed to involve folic acid deprivation but newer mechanisms not related to folic acid have also been suggested, all leading to its recognized anti-inflammatory effects.
✔️ Methotrexate is considered standard of care in conditions like rheumatoid arthritis, psoriatic arthritis, and lupus, particularly when inflammation in the joints is a defining feature of the disease.
✔️ Administration typically involves weekly doses, either orally or via injection, with dosage starting low and gradually titrating up.
✔️ While methotrexate is effective, it can cause side effects such as nausea, mouth ulcers, liver inflammation, low cell counts, and lung injury, which require monitoring and management.

🔗 Links:
Your Appointment Home Run Handbook - [ Ссылка ]
The guide you need to be able to tell your doc your story -and find get answers once and for all!

WellBel hair supplement: [ Ссылка ]

⏱️Time Stamps:
0:00 Intro
00:50 How Methotrexate Works
2:24 Why we use Methotrexate
3:44 How to take Methotrexate
6:32 Methotrexate Side Effects

🎥 watch more:
How to treat Rheumatoid Arthritis pt 1: [ Ссылка ]
How to treat Rheumatoid Arthritis pt 2: [ Ссылка ]

📖 References:
Kalantzis, A., Marshman, Z., Falconer, D. T., Morgan, P. R., & Odell, E. W. (2005). Oral effects of low-dose methotrexate treatment. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 100(1), 52–62.
Ancuta, I. et al. The Amazing history of methotrexate - 75 years later from its discovery, still the “golden standard” therapy. Romanian Journal of Military Medicine. Feb 2023, No. 1.

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👩🏻‍⚕️ About me:
Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor.

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** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.**

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