If you can get directly behind her she cannot really hit you so aim for that. If she keeps turning around and you can only hit her side, just do a couple swings (depending on your weapon speed ofc..) and dodge her tentacle attaks. At about 50% she will start kinda glowing and being near her causes frenzy, so some frenzy resistance will help you. When she start shooting lasers RUN, one burst will most likely kill you.

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