The loss of Dr Manning's wedding ring reveals her difficulty in letting go.

Season 1 Episode 17 "Withdrawal"
Dr. Halstead and April butt heads when it comes to treating a patient with severe alcohol withdrawals and a broken leg. Meanwhile, Dr. Manning has a cardiac event when she loses her wedding ring, Dr. Rhodes is forced to perform bloodless surgery because of a patient who is a Jehovah's Witness and won't take a blood transfusion. Reese and Dr. Charles deals with elderly patients with the same symptoms.

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