Mutations in Dachsous1 are known to cause Van Maldergem syndrome, but the cellular mechanisms by which this protein contributes to organogenesis are unknown. In their recent paper in Development, Solnica-Krezel and colleagues examined the role of dchs1b and dchs2 in the zebrafish, showing that they organize actin and microtubule networks, sometimes independently of their known ligand Fat, to control several aspects of embryogenesis. This movie shows the movements of the cytoplasm within a normal zebrafish embryo, examined by particle image velocimetry analysis. These movements were impaired in dchs1b mutants, suggesting defects in the actin cytoskeleton.
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