Brand Name: Januvia
Generic Name: Sitagliptin
Drug Class: Antidiabetics, Dipeptyl Peptidase-IV Inhibitors
Sitagliptin Tablets: Sitagliptin 25 mg, Sitagliptin 50 mg, Sitagliptin 100 mg.
WHAT IS SITAGLIPTIN AND HOW DOES IT WORK?
Sitagliptin is a prescription medication used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
Sitagliptin is an anti-diabetic drug that works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes.
Sitagliptin is available under the following different brand names: Januvia.
DOSAGES OF SITAGLIPTIN
Tablet
Sitagliptin 25 mg
Sitagliptin 50 mg
Sitagliptin 100 mg
Dosage Considerations – Should be Given as Follows:
Diabetes Mellitus, Type 2
100 mg orally once daily
Dosing Modifications
Renal impairment
Creatinine clearance over 50 ml/minute: dose adjustment not necessary
Creatinine clearance 30-50 ml/minute: 50 mg orally once daily
Creatinine clearance under 30 ml/minute: 25 mg orally once daily
ESRD: 25 mg orally once daily regardless of hemodialysis
Hepatic impairment
Mild to moderate impairment: dose adjustment not necessary
Severe impairment: not studied
Pediatric:
Safety and efficacy not established
