Shubh Goel, VP, Head of Immunoncology and GI Tumors Franchise at AstraZeneca discusses data presented at the European Society for Medical Oncology (ESMO) 2023 from the MATTERHORN Phase 3 trial data where patients with gastric and gastroesophageal junction cancers are treated with IMFINZI ® (durvalumab) + chemotherapy. The data discusses the improvement seen in patients who were treated with this combination therapy versus receiving the current standard of care, which is just chemo. This treatment has not been FDA approved.

#AstraZeneca

Born and raised in London by a mother who owned a clothing store and a father who she describes as a “science nerd,” Shubh Goel initially thought she’d follow in her mother’s footsteps traveling the world and working in fashion. But she ultimately fell in love with science and built a career in healthcare that inspires her every day.

Finding Her Way to Science

Shubh studied biochemistry at the University of Bath In the UK. The field excited her, helping her connect the dots and understand the intricacies of how the human body works.

I actually loved it more than I would have ever thought I would, because I went into it with some naivety.

Studying the immune system and the relationship to various diseases, created an ah-ha moment for Shubh, painting a clear picture of the molecular and chemical components and its connections to what was happening in a disease state, “and that’s what actually switched a light on for me,” Shubh explained.

Shubh’s first industry role was in the UK, in research at Pfizer in the immunology division. After transferring over to the commercial side of the business, somewhat by accident, she moved to the US with Takeda (Millennium Pharmaceuticals at the time) where she was introduced to oncology, as the organization was preparing for an accelerated approval. Hearing a patient’s first-hand experience about her prognosis, care, and clinical trial experience was moving and motivating all at the same time.

“When the patient came in to speak to our team and shared that she was given a devastating prognosis before enrolling in a clinical trial and was standing in front of us at a timepoint when she didn’t expect to be alive, there wasn’t dry eye in the room. That story and the impact that cancer therapies can have on someone’s life ignited a passion in me, keeping me committed to the Oncology space. I have never forgotten that moment and I never looked back. From then on, it was oncology all the way.” From this point forward Shubh was committed to not only bringing new cancer therapies to patients and their loved ones, but also advocating for people living with cancer, as much as she was able.

Building a Career in Oncology

Shubh then pivoted and took on several different commercial oncology roles. She has collaborated with scientists supporting the development of pipeline therapies and worked with sales and marketing teams, preparing to bring new medicines to patients. In her most recent role before AstraZeneca, Shubh was the Chief Commercial Officer for Fennec Pharmaceuticals, a late-stage biotechnology company dedicated to improving the lives of children with cancer. Then in March 2022, Shubh relocated from the New York City area to the D.C. area to join AstraZeneca as the VP, Head of Immuno-Oncology and Gastrointestinal (GI) Tumors Franchise for US Oncology, overseeing sales, marketing, and cross-functional efforts across the Immuno-Oncology portfolio of indications across tumors, and leading the GI sales team across indications in GI tumors.

For Shubh, the position at AstraZeneca felt as if all of her passions came together.

It gave me a chance to be a part of an organization a company that is at forefront of science.
Shubh Goel

“It also gave me the ability to build a team that was gearing up to bring new innovations to patients in a disease area [GI cancer] we hadn’t been in before. Finally, it allowed me to work in immuno-oncology alongside incredible people all focused on the right things -- bringing solutions to patients in need. It felt like a place that I really wanted to be.”


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