Dr. Barkin provides an introduction to the complexity science and life course research. She illustrates the importance of asking how health and disease develope over time by providing 3 complex disease examples. Story 1: CMV exposure and immune functioning. Story 2: The development of Alzheimer disease. Story 3: The emergence of Type 2 Diabetes over time. She also discusses how dose, duration, and timing are important in understanding the emergence of health and disease over time. The PRISM model is a conceptual model that allows an understanding of trajectories of health and disease.
