Psoriasis is a chronic inflammatory disease that is characterized by the presence of pruritic skin lesions. Aberrant interactions between the epithelia and immune system underlie the disease; however, the pathways that promote psoriasis are poorly understood. In this episode, Peter Marinkovich and Mårten Winge discuss their work, which shows that hyperactivation of RAC1 in the skin drives pathogenic interactions between the epidermis and the immune system in psoriasis. The results of this work suggest that RAC1 is a potential therapeutic target for this disease.
