Dr. Mark Pimentel from the MAST program and Cedars-Sinai answers my potpourri of questions about SIBO/IMO/IBS and other aspects of gastrointestinal health

If you are new to SIBO/IMO/IBS, please watch my playlist here:
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Time stamps for questions/topics:
0:00 Intro
1:19 Percentage of patients with SIBO/IMO that present with typical IBS-D/IBS-C
2:57 Lower abdominal symptoms vs. upper abdominal symptoms and post-infectious functional dyspepsia
4:18 Hypotheses on why someone might present with upper vs. lower abdominal symptoms
4:38 IBS Smart test, anti-CdtB and anti-vinculin antibodies and damage to GI tract, visceral myopathy, pseduo-obstruction
5:34 gastroparesis
6:11 diagram of IBS microtypes
6:56 is a hydrogen microtype associated with diarrhea
8:31 diarrhea vs. constipation and microbial diversity
10:08 how rifaximin helps SIBO patients return to a more normal small bowel micobiome
11:56 synergy between antibiotics and our immune systems
15:13 can you get SIBO from antibiotics
19:22 are there studies in the works to find antimicrobials that target methanogens (which are archaea and not bacteria)
20:47 what are factors that contribute to whether or not someone develops SIBO after food poisoning
22:31 virulence of different bacteria
23:35 food poisoning while abroad
24:52 once anti-vinculin antibodies go positive to negative, is a person still more likely to get SIBO than someone who has never had SIBO/anti-vinculin antibodies
27:02 what might be the future for treatment of anti-vinculin antibodies
29:28 if a patient doesn’t get on a prokinetic, can they swing from SIBO to IMO or vice versa?
31:07 relationship between SIBO/IMO and MCAS
33:41 biofilms and SIBO and Breaking News?!
35:09 sulfur sensitivity and hydrogen sulfide SIBO
37:24 how H2S is produced, dissimilatory/assimilatory sulfate reduction pathways
39:03 inflammatory cytokines and SIBO/IMO
42:38 immune system is redudant
45:01 stop calling the stool microbiome the gut microbiome!
46:32 how high H2S affects gut cells and other parts of body
48:55 where is H2S most populated in the GI tract and more Breaking News!
49:46 does immodium make one more likely to develop SIBO after food poisoning, instead get an antibiotic
51:58 How can we speed up research to help patients

References:
1. Rizos, E., Pyleris, E., Pimentel, M., Triantafyllou, K., & Giamarellos-Bourboulis, E. J. (2022). Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study. Microorganisms, 10(5), 960.
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2. Casadevall, A., & Pirofski, L. A. (2014). Microbiology: ditch the term pathogen. Nature, 516(7530), 165-166.
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