The re-imposition of the full panoply of sanctions against Iran that were waived under the Joint Comprehensive Plan of Action (JCPOA) nuclear agreement marks a high-point for President Donald Trump's foreign policy.
Iran's President Hassan Rouhani has vowed to "break" swingeing sanctions re-imposed by the US targeting core parts of the economy.
The Trump administration is restoring all sanctions lifted under the 2015 nuclear deal in a bid to pressure Iran.
They will hit oil exports, shipping and banks, and make it difficult to do business with the oil-rich nation.
But Mr Rouhani struck a defiant tone, saying that Iran would "continue selling oil".
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